PD/PDT for gynecological disease: A clinical review

Allison, R.R.; Cuenca, R.; Downie, G.H.; Randall, M.E.; Bagnato, V.S.; Sibata, C.H.

doi:10.1016/S1572-1000(05)00033-5

« Previous Next »Photodiagnosis and Photodynamic Therapy
Volume 2, Issue 1 , Pages 51-63, March 2005

PD/PDT for gynecological disease: A clinical review

R.R. Allison
- Department of Radiation Oncology, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
- PDT Center, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
R. Cuenca
- PDT Center, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
- Surgical Oncology Department, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
G.H. Downie
- PDT Center, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
- Pulmonary and Critical Care Medicine Department, The Brody School of Medicine at East Carolina University, Greenville, 600 Moye Blvd., LJCC 172, NC 27858, USA
M.E. Randall
- Department of Radiation Oncology, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
- PDT Center, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
V.S. Bagnato
- University of São Paulo-São Carlos, Physics Department, São Carlos, SP, Brazil
C.H. Sibata, PhD
- Department of Radiation Oncology, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
- PDT Center, The Brody School of Medicine at East Carolina University, 600 Moye Blvd., LJCC 172, Greenville, NC 27858, USA
- Corresponding author. Tel.: +1 252 744 2900; fax: +1 425 940 3498.

Summary

The evolution of diagnostic and interventional procedures for gynecologic disease has led to organ, sexual and reproductive sparing treatments. Photodiagnosis (PD) and photodynamic therapy (PDT) may play a great role for gynecological patients as both offer the potential to achieve these goals.

PD/PDT for a wide variety of diagnostic and therapeutic interventions have shown potential for excellent clinical outcomes. However, significant limitations remains, both clinically and dosimetrically, that prevent consistent results. When those limitations are resolved PD/PDT could move to the forefront of gynecological therapy.

This clinical review highlights the outcomes and shortcomings of PD/PDT through the peer reviewed literature for gynecological sites.

Keywords: Photodynamic therapy, Gynecological disease, Photodiagnosis, PD, PDT