Photodiagnosis and Photodynamic Therapy
Volume 2, Issue 1 , Pages 35-44 , March 2005

Photodynamic therapy and endoscopic mucosal resection as minimally invasive approaches for the treatment of early esophageal tumors: Pre-clinical and clinical experience in Lausanne

  • A. Radu, MD

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, CHUV Hospital, CH-1011 Lausanne, Switzerland
    • Corresponding Author InformationCorresponding author. Tel.: +41 21 314 27 00; fax: +41 21 314 27 06.
    • ,
  • P. Grosjean

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, CHUV Hospital, CH-1011 Lausanne, Switzerland
    • ,
  • Y. Jaquet

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, CHUV Hospital, CH-1011 Lausanne, Switzerland
    • ,
  • R. Pilloud

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, CHUV Hospital, CH-1011 Lausanne, Switzerland
    • ,
  • G. Wagnieres

      Affiliations

    • Institute of Environmental Engineering, EPFL, CH-1015 Lausanne, Switzerland
    • ,
  • H. van den Bergh

      Affiliations

    • Institute of Environmental Engineering, EPFL, CH-1015 Lausanne, Switzerland
    • ,
  • Ph. Monnier

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, CHUV Hospital, CH-1011 Lausanne, Switzerland

References 

  1. Coia LR, Sauter ER. Esophageal cancer. Curr Probl Cancer. 1994;18:189–247
  2. Moses FM. Squamous cell carcinoma of the esophagus. Natural history, incidence, etiology, and complications. Gastroenterol Clin North Am. 1991;20:703–716
  3. Perrachia A. Squamous carcinoma of the esophagus. Hepatogastroenterology. 1990;37:358–359
  4. Endo M, Takeshita K, Yoshida M. How can we diagnose the early stage of esophageal cancer?. Endoscopy. 1986;18:11–18
  5. Gore RM. Esophageal cancer. Clinical and pathologic features. Radiol Clin North Am. 1997;35:243–263
  6. Ban S, Toyonaga A, Harada H, Ikejiri N, Tanikawa K. Iodine staining for early endoscopic detection of esophageal cancer in alcoholics. Endoscopy. 1998;30:253–257
  7. Fleischer D. Four things to recall about esophageal cancer. Endoscopy. 1998;30:311–312
  8. Kato H. Diagnosis and treatment of esophageal neoplasms. Jpn J Cancer Res. 1997;86:993–1009
  9. Roth JA, Putman JB. Surgery for cancer of the esophagus. Semin Oncol. 1994;4:453–461
  10. Earlam R, Cunha-Melo JR. Esophageal squamous cell carcinoma: a critical review of radiotherapy. Br J Surg. 1980;67:457–461
  11. Collard JM, Otte JB, Reynaert M, Kestens PJ. Quality of life three years or more after esophagectomy for cancer. J Thorac Cardiovasc Surg. 1992;104:391–394
  12. Overholt BF. Laser and photodynamic therapy of esophageal cancer. Semin Surg Oncol. 1992;8:191–203
  13. Gossner L, May A, Stolte M, Seitz G, Hahn EG, Ell C. KTP laser destruction of dysplasia and early cancer in columnar-lined Barrett's esophagus. Gastrointest Endosc. 1999;49:8–12
  14. Sampliner RE, Hixson LJ, Fennerty MB, Garewal HS. Regression of Barrett's esophagus by laser ablation in an anacid environment. Dig Dis Sci. 1993;38:365–368
  15. Schultz H, Mielhke S, Antos D, et al. Ablation of Barrett's epithelium by endoscopic argon plasma coagulation in combination with high-dose omeprazole. Gastrointest Endosc. 2000;51:659–663
  16. Van Laethem JL, Cremer M, Peny MO, Delhaye M, Deviere J. Eradication of Barrett's mucosa with argon plasma coagulation and acid suppression: immediate and mid term results. Gut. 1998;43:747–751
  17. Sharma P, Bhattacharyya A, Garewal HS, Sampliner RE. Durability of new squamous epithelium after endoscopic reversal of Barrett's esophagus. Gastrointest Endosc. 1999;50:159–164
  18. Savary JF, Grosjean P, Monnier P, et al. Photodynamic therapy of early squamous cell carcinomas of the esophagsu: a review of 31 cases. Endoscopy. 1998;30:258–265
  19. Overholt BF, Panjehpour M, Haydek JM. Photodynamic therapy for Barrett's esophagus: follow-up in 100 patients. Gastrointest Endosc. 1999;49:1–7
  20. Inoue H, Takeshita K, Hori H, Muraoka Y, Yoneshima H, Endo M. Endoscopic mucosal resection with a cap-fitted panendoscope for esophagus, stomach, and colon mucosal lesions. Gastrointest Endosc. 1993;39:58–62
  21. Nijhawan PK, Wang KK. Endoscopic mucosal resection for lesions with endoscopic features suggestive of malignancy and high-grade dysplasia within Barrett's esophagus. Gastrointest Endosc. 2000;52:328–332
  22. Ell C, May A, Gossner L, et al. Endoscopic mucosal resection of early cancer and high-grade dysplasia in Barrett's esophagus. Gastroenterology. 2000;118:670–677
  23. Fisher AMR, Murphree L, Gomer CJ. Clinical and preclinical photodynamic therapy. Lasers Surg Med. 1995;17:2–31
  24. Rösch T, Sarbia M, Schumacher B, Deinert K, Frimberger E, Toermer T. Attempted endoscopic en bloc resection of mucosal and submucosal tumors using insulated tip knives: a pilot series. Endoscopy 2004;36:788–801.
  25. Berenbaum MC, Akande SL, Bonnett R, et al. meso-Tetra(hydroxyphenyl) porphyrins, a new class of potent tumours photosensitizers with favourable selectivity. Br J Cancer. 1986;54:717–725
  26. Monnier P, Fontolliet C, Ollyo JB. Endoscopic findings of 100 early-stage esophageal cancers. Diagn Ther Endosc. 1994;1:83–92
  27. Van den Bergh H. On the evolution of some endoscopic light delivery systems for photodynamic therapy. Endoscopy. 1998;30:392–407
  28. Wagnieres G, Hadjur C, Grosjean P, et al. Clinical evaluation of the cutaneous phototoxicity of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin. Photochem Photobiol. 1998;68:382–387
  29. Grosjean P. La mucosectomie endoscopique oesophagienne: étude pré-clinique. Probl Actuelles Otorhinolaryngol. 1998;21:293–302
  30. Khaw PT, Doyle JW, Sherwood MB, Smith MF, McGorray S. Prolonged localized tissue effects from 5-minute exposure to fluorouracil and mitomycin C. Arch Ophtalmol. 1993;111:263–267
  31. Rahbar R, Jones DT, Nuss RC, et al. The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract: friend or foe?. Arch Otolaryngol Head Neck Surg. 2002;128:401–406
  32. Eliashar R, Eliachar I, Esclamado R, Gramlich T, Strome M. Can topical mitomycin prevent laryngotracheal stenosis?. Laryngoscope. 1999;109:1594–1600
  33. Liu JB, Miller LS, Goldberg BB, et al. Transnasal US of the esophagus: preliminary morphologic and function studies. Radiology. 1992;184:721–727
  34. Bays R, Wagnieres G, Robert D, et al. Light dosimetry for photodynamic therapy in the esophagus. Lasers Surg Med. 1997;20:290–303
  35. Braichotte DR, Savary JF, Monnier P, van den Bergh H. Optimizing light dosimetry in photodynamic therapy of early stage carcinomas of the esophagus using fluorescence spectroscopy. Lasers Surg Med. 1996;19:340–346
  36. Radu A, Conde R, Fontolliet C, Wagnieres , van den Bergh H, Monnier P. Mucosal ablation with photodynamic therapy in the esophagus: optimisation of light dosimetry in the sheep model. Gastrointest Endosc. 2003;57:897–905
  37. May A, Gossner L, Pech O, et al. Intraepithelial high-grade neoplasia and early adenocarcinoma in short-segment Barrett's esophagus: curative treatment using local endoscopic treatment techniques. Endoscopy. 2002;34:604–610
  38. Kida M. Endoscopic tumor diagnosis and treatment. Endoscopy. 2000;32:836–844Ackroyd R, Brown NJ, Stephenson TJ, Stoddard CJ, Reed MW. Ablation treatment for Barrett's esophagus: what depth of tissue distruction is needed. J Clin Pathol. 1999;52:509–512
  39. Kuwano H, Mochiki E, Asao T, Kato H, Shimura T, Tsutsumi S. Double endoscopic intraluminal operation for upper digestive tract diseases: proposal of anovel procedure. Ann Surg 2004;239:(1):22–7.
  40. Rajan E, Gostout CJ, Feitoza AB, Leontovich ON, Herman LJ. Widespread EMR: a new technique for removal of large areas of mucosa. Gastrointest Endosc 2004;60:623–27.
  41. Ackroyd R, Brown NJ, Stephenson TJ, Stoddard CJ, Reed MW. Ablation treatment for Barrett's esophagus: what depth of tissue distruction is needed. J Clin Pathol 1999;52:509–512.
  42. Conio M, Sorbi D, Batts KP, Gostout CJ. Endoscopic circumferential esophageal mucosectomy in a porcine model: an assessment of technical feasibility, safety, and outcome. Endoscopy. 2001;33:791–794
    References
  1. Weston AP, Sharma P, Topalovski , Richards R, Cherian R, Dixon A. Long-term follow-up of Barrett's high-grade dysplasia. Am J Gastroenterol. 2000;95:1888–1893
  2. Jankowski J, Harrison RF, Perry I, Balkwill F, Tselepis C. Barrett's metaplasia. Lancet. 2000;356:2079–2086
  3. Pellegrini CA, Pohl D. High-grade dysplasia in Barrett's esophagus: surveillance or operation?. J Gastrointest Surg. 2000;4:131–134
  4. Buttar NS, Wang KK, Sebo TJ, et al. Extent of high-grade dysplasia in Barrett's esophagus correlates with risk of adenocarcinoma. Gastroenterology. 2001;120:1630–1639
  5. Schnell TG, Sontag SJ, Chejfec G, et al. Long-term nonsurgical management of Barrett's esophagus with high-grade dysplasia. Gastroenterology. 2001;120:1607–1619
  6. Bachmann MO, Alderson D, Edwards D, et al. Cohort study in South and West England of the influence of specialization on the management and outcome of patients with oesophageal and gastric cancers. BJS. 2002;89:914–922
  7. Bollschweiler E, Schroder W, Holscher AH, Siewert JR. Preoperative risk analysis in patients with adenocarcinoma or squamous cell carcinoma of the oesophagus. BJS. 2000;87:1106–1110
  8. Zaninotto , Parenti AR, Ruol A, Costantini M, Merigliano S, Ancona E. Oesophageal resection for high-grade dysplasia in Barrett's oesophagus. BJS. 2000;97:1102–1105
  9. Barr H, Shepherd NA, Dix A, Roberts DJH, Tan WC, Krasner N. Eradication of highgrade dysplasia in columnar-lined (Barrett's) oesophagus using photodynamic therapy withendogenously generated protoporphyrin IX. Lancet. 1996;348:584–585
  10. Gossner L, Stolte M, Stroke R, et al. Photodynamic therapy of high-grade dysplasia and early stage carcinomas by means of 5-aminolaevulinic acid. Gastroenterology. 1998;114:447–455
  11. Biddlestone LR, Barham CP, Wilkinson SP, Barr H, Shepherd NA. The histopathology of treated Barrett's Oesophagus: squamous re-epithelialisation following acid suppression, laser and photodynamic therapy. Am J Surg Pathol. 1998;22:239–245
  12. Barr H. Barrett's esophagus: treatment with 5-aminolevulinic acid photodynamic therapy gastrointestinal endoscopy. Clin North Am. 2000;10:421–438

PII: S1572-1000(05)00035-9

doi: 10.1016/S1572-1000(05)00035-9

Photodiagnosis and Photodynamic Therapy
Volume 2, Issue 1 , Pages 35-44 , March 2005

Article Tools

* Image Usage & Resolution