Photodiagnosis and Photodynamic Therapy
Volume 2, Issue 3 , Pages 193-196, September 2005

Lipophilic cationic porphyrins as photodynamic sensitisers—Synthesis and structure–activity relationships

Department of Chemistry, University of Hull, Kingston-upon-Hull, East Yorkshire HU6 7RX, UK

published online 27 October 2005.

Summary 

A convenient synthesis of a range of phosphorous and nitrogen centred lipophilic cationic porphyrins is described. In vitro assays for photodynamic activity against human colorectal adenocarcinoma cells (HT-29) reveal significant differences based on substituents around the cation centres.

Keywords: Photodynamic therapy, Cationic porphyrins, Structure–activity relationships

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PII: S1572-1000(05)00065-7

doi:10.1016/S1572-1000(05)00065-7

Photodiagnosis and Photodynamic Therapy
Volume 2, Issue 3 , Pages 193-196, September 2005

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