Photodiagnosis and Photodynamic Therapy
Volume 3, Issue 3 , Pages 177-183 , September 2006

Fab fragment labeled with ICG-derivative for detecting digestive tract cancer

  • Hiromi Yano

      Affiliations

    • Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City 770-8503, Japan
    • ,
  • Naoki Muguruma, MD, PhD

      Affiliations

    • Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City 770-8503, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 88 633 7124; fax: +81 88 633 9235.
    • ,
  • Susumu Ito

      Affiliations

    • Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City 770-8503, Japan
    • ,
  • Eriko Aoyagi

      Affiliations

    • Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City 770-8503, Japan
    • ,
  • Tetsuo Kimura

      Affiliations

    • Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City 770-8503, Japan
    • ,
  • Yoshitaka Imoto

      Affiliations

    • Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City 770-8503, Japan
    • ,
  • Jianxin Cao

      Affiliations

    • Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City 770-8503, Japan
    • Present address: The First City Hospital of Changzhou, Changzhou, China
    • ,
  • Shohei Inoue

      Affiliations

    • Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Institute of Health Biosciences, Tokushima, Japan
    • ,
  • Shigeki Sano

      Affiliations

    • Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Institute of Health Biosciences, Tokushima, Japan
    • ,
  • Yoshimitsu Nagao

      Affiliations

    • Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Institute of Health Biosciences, Tokushima, Japan
    • ,
  • Hiroshi Kido

      Affiliations

    • Division of Enzyme Chemistry, The Institute for Enzyme Research, The University of Tokushima Graduate School, Tokushima, Japan

References 

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  2. Muguruma N, Ito S, Hayashi S, et al. Antibodies labeled with fluorescence-agent excitable by infrared rays. J Gastroenterol. 1998;33:467–471
  3. Ito S, Muguruma N, Kusaka Y, et al. Detection of human gastric cancer in resected specimens using a novel infrared fluorescent anti-human carcinoembryonic antigen antibody with an infrared fluorescence endoscope in vitro. Endoscopy. 2001;33:849–853
  4. Tadatsu Y, Muguruma N, Ito S, et al. Optimal labeling condition of antibodies available for immunofluorescence endoscopy. J Med Invest. 2006;53:52–60
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  7. Utsunomiya T, Yonezawa S, Sakamoto H, et al. Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin Cancer Res. 1998;4:2605–2614
  8. Bando T, Muguruma N, Ito S, et al. Basic studies on a labeled anti-mucin antibody detectable by infrared-fluorescence endoscopy. J Gastroenterol. 2002;37:260–269
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  17. Borotto E, Englender J, Pourny JC, et al. Detection of the fluorescence of GI vessels in rats using a CCD camera or a near-infrared video endoscope. Gastrointest Endosc. 1999;50:684–688
  18. Williams RJ, Narayanan N, Casay GA, et al. Instrument to detect near-infrared fluorescence in solid-phase immunoassay. Anal Chem. 1994;66:3102–3107
  19. Muguruma N, Ito S, Bando T, et al. Labeled carcinoembryonic antigen antibodies excitable by infrared rays: a novel diagnostic method for micro cancers in the digestive tract. Intern Med. 1999;38:537–542
  20. Tadatsu M, Ito S, Muguruma N, et al. A new infrared fluorescent-labeling agent and labeled antibody for diagnosing microcancers. Bioorg Med Chem. 2003;11:3289–3294
  21. Inayama K, Ito S, Muguruma N, et al. Basic study of an agent for reinforcement of near-infrared fluorescence on tumor tissue. Dig Liver Dis. 2003;35:88–93
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PII: S1572-1000(06)00060-3

doi: 10.1016/j.pdpdt.2006.03.012

Photodiagnosis and Photodynamic Therapy
Volume 3, Issue 3 , Pages 177-183 , September 2006

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