Photodiagnosis and Photodynamic Therapy
Volume 3, Issue 3 , Pages 162-167, September 2006

Potential of cationic porphyrins for photodynamic treatment of cutaneous Leishmaniasis

  • Carrie-Anne Bristow

      Affiliations

    • Photobiology and Photomedicine Group, Department of Chemistry & Clinical Biosciences Institute, University of Hull, Kingston-upon-Hull HU6 7RX, United Kingdom
    • ,
  • Robert Hudson

      Affiliations

    • Photobiology and Photomedicine Group, Department of Chemistry & Clinical Biosciences Institute, University of Hull, Kingston-upon-Hull HU6 7RX, United Kingdom
    • ,
  • Timothy A. Paget, PhD

      Affiliations

    • Medway School of Pharmacy, The Universities of Kent and Greenwich at Medway, Kent ME4 4TB, United Kingdom
    • Corresponding Author InformationCorresponding author.
    • ,
  • Ross W. Boyle, PhD

      Affiliations

    • Photobiology and Photomedicine Group, Department of Chemistry & Clinical Biosciences Institute, University of Hull, Kingston-upon-Hull HU6 7RX, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 1482 466353; fax: +44 1482 466410.

published online 07 July 2006.

Summary 

Four tetracationic porphyrins have been investigated for their ability to photo-inactivate Leishmania major promastigotes. Parallel photocytotoxicity assays against keratinocytes and macrophages show significant differences in activity between the microorganism and mammalian cells. Results suggest that it may be possible to photodynamically inactivate macrophages infected with Leishmania and the promastigote form of the microorganism, while minimising damage to surrounding tissue.

Keywords: Leishmaniasis, Photodynamic therapy, Porphyrins

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PII: S1572-1000(06)00064-0

doi:10.1016/j.pdpdt.2006.04.004

Photodiagnosis and Photodynamic Therapy
Volume 3, Issue 3 , Pages 162-167, September 2006

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