Photodiagnosis and Photodynamic Therapy
Volume 3, Issue 4 , Pages 227-233 , December 2006

Early apoptotic responses in transgenic mouse mammary carcinoma for photodynamic therapy

  • Heinrich Walt, PhD

      Affiliations

    • Research Division of Gynaecology, Department of Obstetrics and Gynaecology, University Hospital, Zurich, CH-8091, Switzerland
    • Corresponding Author InformationCorresponding author. Tel.: +41 1 255 5372; fax: +41 1 255 4553.
    • ,
  • Marius Nap

      Affiliations

    • Department of Pathology, Atrium Heerlen Medical Centre, Heerlen, CX, 4446 6401, The Netherlands
    • ,
  • Ann M. Dorward

      Affiliations

    • The Jackson Laboratory, Bar Harbor, ME 04609, USA
    • ,
  • Mathie P.G. Leers

      Affiliations

    • Department of Pathology, Atrium Heerlen Medical Centre, Heerlen, CX, 4446 6401, The Netherlands
    • ,
  • Barbara J. Tennent

      Affiliations

    • The Jackson Laboratory, Bar Harbor, ME 04609, USA
    • ,
  • Zsuzsanna Varga

      Affiliations

    • Department of Pathology, University Hospital, Zurich, CH-8091, Switzerland
    • ,
  • Thomas Stallmach

      Affiliations

    • Department of Pathology, University Hospital, Zurich, CH-8091, Switzerland
    • ,
  • Viveka Björklund

      Affiliations

    • Cancer Council, Bromma, SE 16762, Sweden
    • ,
  • Wesley G. Beamer

      Affiliations

    • The Jackson Laboratory, Bar Harbor, ME 04609, USA

References 

  1. Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. Natl Cancer Inst. 1998;90:889–905
  2. Kaneko T, Chiba H, Yasuda T, Kusama K. Detection of photodynamic therapy-induced early apoptosis in human salivary gland tumor cells in vitro and in a mouse tumor model. Oral Oncol. 2004;40:787–792
  3. Leers MPG, Kölgen W, Björklund V, et al. Immuncytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J Pathol. 1999;187:567–572
  4. Leers MPG, Schutte B, Theunissen PHMH, Ramaekers FCS, Nap M. Heat pretreatment enables high resolution DNA flow cytometry of paraffin embedded tumor tissue. Cytometry. 1999;35:260–266
  5. Andres A, Schonenberger C, Groner B, Hennighausen L, LeMeur M, Gerlinger P. Ha-ras oncogene expression directed by a milk protein gene promoter: Tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Proc Natl Acad A Sci USA. 1987;84:1299–1303
  6. Nielsen L, Discafani C, Gurnani M, Tyler R. Histopathology of salivary and mammary gland tumors in transgenic mice expressing a human Ha-ras oncogene. Cancer Res. 1991;51:3762–3767
  7. Hornung R, Fehr MK, Walt H, Wyss P, Berns MW, Tadir Y. PEG-m-THPC-mediated photodynamic effects on normal rat tissues. Photochem Photobiol. 2000;72:696–700
  8. Westermann P, Glanzmann T, Andrejevic S, et al. Long circulating half-life and high tumour selectivity of the phototsensitizer meta-tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma. Int J Cancer. 1998;76:842–850
  9. Rovers JP, Saarnak AE, de Jode M, Sterenborg HJ, Terpstra OT, Grahn MF. Biodistribution and bioactivity of tetra-pegylated meta-tetra(hydroxyphenyl)chlorin compared to native meta-tetra(hydroxyphenyl)chlorin in a rat liver tumor model. Photochem Photobiol. 2000;71:211–217
  10. Hornung R, Fehr MK, Monti-Frayne J, Tromberg BJ, Berns MW, Tadir Y. Minimally-invasive debulking of ovarian cancer in the rat pelvis by means photodynamic therapy using the pegylated photosensitizer PEG-m-THPC. Br J Cancer. 1999;81:631–637
  11. Zhongping C, Milner TE, Wang X, Srinivas S, Nelson JS. Optical doppler tomography: Imaging in vivo blood flow dynamics following pharmacological intervention and photodynamic therapy. Photochem Photobiol. 1998;67:1–7
  12. Wang I, Andersson-Engels S, Nilsson GE, Wardell K, Svanberg K. Superficial blood flow following photodynamic therapy of malignant skin tumours measured by laser Doppler perfusion imaging. Br J Dermatol 1997;136:184–89.
  13. Ohlerth S, Laluhova D, Buchholz J, Roos M, Walt H, Kaser-Hotz B. Changes in vascularity and blood volume as a result of photodynamic therapy can be assessed with power Doppler ultrasonography. Lasers Surg Med. 2006;38:229–234

PII: S1572-1000(06)00096-2

doi: 10.1016/j.pdpdt.2006.07.002

Photodiagnosis and Photodynamic Therapy
Volume 3, Issue 4 , Pages 227-233 , December 2006

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