Photodiagnosis and Photodynamic Therapy
Volume 3, Issue 4 , Pages 247-258 , December 2006

Apoptosis and expression of cytokines triggered by pyropheophorbide-a methyl ester-mediated photodynamic therapy in nasopharyngeal carcinoma cells

  • K.M. Li

      Affiliations

    • Department of Biology, Hong Kong Baptist University, 224 Waterloo Road, Hong Kong, China
    • Present address: Department of Biochemistry, University of Hong Kong, China.
    • ,
  • X. Sun

      Affiliations

    • Department of Biology, Hong Kong Baptist University, 224 Waterloo Road, Hong Kong, China
    • Present address: The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA.
    • ,
  • H.K. Koon

      Affiliations

    • Department of Biology, Hong Kong Baptist University, 224 Waterloo Road, Hong Kong, China
    • ,
  • W.N. Leung

      Affiliations

    • School of Chinese Medicines, Hong Kong Baptist University, China
    • Present address: The Chinese University of Hong Kong—Tung Wah Group of Hospitals Community College, China.
    • ,
  • M.C. Fung

      Affiliations

    • Department of Biology, Chinese University of Hong Kong, China
    • ,
  • R.N.S. Wong

      Affiliations

    • Department of Biology, Hong Kong Baptist University, 224 Waterloo Road, Hong Kong, China
    • ,
  • Maria L. Lung

      Affiliations

    • Department of Biology, Hong Kong University of Science and Technology, Hong Kong, China
    • ,
  • C.K. Chang

      Affiliations

    • Department of Chemistry, Hong Kong University of Science and Technology, Hong Kong, China
    • ,
  • N.K. Mak, PhD

      Affiliations

    • Department of Biology, Hong Kong Baptist University, 224 Waterloo Road, Hong Kong, China
    • Corresponding Author InformationCorresponding author. Fax: +852 3411 5995.

References 

  1. Brown SB, Brown EA, Walker I. The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol. 2004;5:497–508
  2. Nyman ES, Hynninen PH. Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy. J Photochem Photobiol B. 2004;73:1–28
  3. Oleinick NL, Morris RL, Belichenko I. The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photochem Photobiol Sci. 2002;1:1–21
  4. Ali SM, Olivo M. Mechanisms of action of phenanthroperylenequinones in photodynamic therapy (review). Int J Oncol. 2003;22:1181–1191
  5. Gorman SA, Brown SB, Griffiths J. An overview of synthetic approaches to porphyrin, phthalocyanine, and phenothiazine photosensitizers for photodynamic therapy. J Environ Pathol Toxicol Oncol. 2006;25:71–108
  6. Piette J, Volanti C, Vantieghem A, Matroule JY, Habraken Y, Agostinis P. Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers. Biochem Pharmacol. 2003;66:1651–1659
  7. Villeneuve L. Ex vivo photodynamic purging in chronic myelogenous leukaemia and other neoplasias with rhodamine derivatives. Biotechnol Appl Biochem. 1999;30(Part 1):1–17
  8. Lustig RA, Vogl TJ, Fromm D, et al. A multicenter Phase I safety study of intratumoral photoactivation of talaporfin sodium in patients with refractory solid tumors. Cancer. 2003;98:1767–1771
  9. Tsukagoshi S. Development of a novel photosensitizer, talaporfin sodium, for the photodynamic therapy (PDT). Gan To Kagaku Ryoho. 2004;31:979–985[in Japanese]
  10. Matroule JY, Carthy CM, Granville DJ, Jolois O, Hunt DW, Piette J. Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. Oncogene. 2001;20:4070–4084
  11. Sun X, Leung WN. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002;75:644–651
  12. Xu CS, Leung AW. Photodynamic effects of pyropheophorbide-a methyl ester in nasopharyngeal carcinoma cells. Med Sci Monit. 2006;12:BR257–BR262
  13. Glaser R, Zhang HY, Yao KT, et al. Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomas. Proc Natl Acad Sci USA. 1989;86:9524–9528
  14. Mak NK, Li KM, Leung WN, et al. Involvement of both endoplasmic reticulum and mitochondria in photokilling of nasopharyngeal carcinoma cells by the photosensitizer Zn-BC-AM. Biochem Pharmacol. 2004;68:2387–2396
  15. Mak NK, Leung CY, Wei XY, et al. Inhibition of RANTES expression by indirubin in influenza virus-infected human bronchial epithelial cells. Biochem Pharmacol. 2004;67:167–174
  16. Huang YT, Sheen TS, Chen CL, et al. Profile of cytokine expression in nasopharyngeal carcinomas: a distinct expression of interleukin 1 in tumor and CD4+ T cells. Cancer Res. 1999;59:1599–1605
  17. Mak NK, Kok TW, Wong RN, et al. Photodynamic activities of sulfonamide derivatives of porphycene on nasopharyngeal carcinoma cells. J Biomed Sci. 2003;10:418–429
  18. Anderson TM, Dougherty TJ, Tan D, Sumlin A, Schlossin JM, Kanter PM. Photodynamic therapy for sarcoma pulmonary metastases: a preclinical toxicity study. Anticancer Res. 2003;23:3713–3718
  19. Gollnick SO, Evans SS, Baumann H, et al. Role of cytokines in photodynamic therapy-induced local and systemic inflammation. Br J Cancer. 2003;88:1772–1779
  20. Kelleher DK, Thews O, Scherz A, Salomon Y, Vaupel P. Combined hyperthermia and chlorophyll-based photodynamic therapy: tumour growth and metabolic microenvironment. Br J Cancer. 2003;89:2333–2339
  21. Lee WY, Lim DS, Ko SH, et al. Photoactivation of pheophorbide a induces a mitochondrial-mediated apoptosis in Jurkat leukaemia cells. J Photochem Photobiol B. 2004;75:119–126
  22. Lim DS, Ko SH, Lee WY. Silkworm-pheophorbide alpha mediated photodynamic therapy against B16F10 pigmented melanoma. J Photochem Photobiol B. 2004;74:1–6
  23. Snyder JW, Greco WR, Bellnier DA, Vaughan L, Henderson BW. Photodynamic therapy: a means to enhanced drug delivery to tumors. Cancer Res. 2003;63:8126–8131
  24. Pandey RK, Sumlin AB, Constantine S, et al. Alkyl ether analogs of chlorophyll-a derivatives: Part 1. Synthesis, photophysical properties and photodynamic efficacy. Photochem Photobiol. 1996;64:194–204
  25. Volanti C, Gloire G, Vanderplasschen A, Jacobs N, Habraken Y, Piette J. Downregulation of ICAM-1 and VCAM-1 expression in endothelial cells treated by photodynamic therapy. Oncogene. 2004;23:8649–8658
  26. Matroule JY, Bonizzi G, Morliere P, et al. Pyropheophorbide-a methyl ester-mediated photosensitization activates transcription factor NF-kappaB through the interleukin-1 receptor-dependent signaling pathway. J Biol Chem. 1999;274:2988–3000
  27. Castano AP, Mroz P, Hamblin MR. Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer. 2006;6:535–545
  28. Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90:889–905
  29. Du H, Bay BH, Mahendran R, Olivo M. Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer. Cancer Lett. 2005;
  30. Du H, Bay BH, Mahendran R, Olivo M. Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy. Int J Mol Med. 2002;10:73–76
  31. Usuda J, Okunaka T, Furukawa K, et al. Increased cytotoxic effects of photodynamic therapy in IL-6 gene transfected cells via enhanced apoptosis. Int J Cancer. 2001;93:475–480
  32. Jee SH, Shen SC, Chiu HC, Tsai WL, Kuo ML. Overexpression of interleukin-6 in human basal cell carcinoma cell lines increases anti-apoptotic activity and tumorigenic potency. Oncogene. 2001;20:198–208
  33. Patel VP, Kreider BL, Li Y, et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J Exp Med. 1997;185:1163–1172
  34. Nardelli B, Morahan DK, Bong GW, Semenuk MA, Kreider BL, Garotta G. Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-gamma and CD40 ligation. J Leukoc Biol. 1999;65:822–828
  35. Forssmann U, Delgado MB, Uguccioni M, Loetscher P, Garotta G, Baggiolini M. CKbeta8 a novel CC chemokine that predominantly acts on monocytes. FEBS Lett. 1997;408:211–216
  36. Youn BS, Zhang SM, Broxmeyer HE, et al. Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. Blood. 1998;91:3118–3126
  37. Grzegorzewski KJ, Yao XT, Kreider B, et al. Analysis of eosinophils and myeloid progenitor responses to modified forms of MPIF-2. Cytokine. 2001;13:209–219
  38. White JR, Imburgia C, Dul E, et al. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. J Leukoc Biol. 1997;62:667–675

PII: S1572-1000(06)00118-9

doi: 10.1016/j.pdpdt.2006.09.001

Photodiagnosis and Photodynamic Therapy
Volume 3, Issue 4 , Pages 247-258 , December 2006

Article Tools

* Image Usage & Resolution