Photodynamic therapy plus topical retinoids in Darier's disease

Amerio, Paolo; Gobello, Tommaso; Mazzanti, Cinzia; Giaculli, Eugenia; Ruggeri, Salvatore; Sordi, Donatella; Amatetti, Massimo; Chinni, Luca; Tulli, Antonio

doi:10.1016/j.pdpdt.2006.09.002

« Previous Next »Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 1 , Pages 36-38, March 2007

Photodynamic therapy plus topical retinoids in Darier's disease

Paolo Amerio, MD, PhD
- Dept of Dermatology, University G.D’Annunzio, Chieti, Italy
- Corresponding author at: Università G. D’Annunzio, Ospedale SS Annunziata, Clinica Dermatologica, Via dei Vestini 66013, Chieti, Italy. Tel.: +39 0871358040; fax: +39 0871551057.
Tommaso Gobello
- Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy
Cinzia Mazzanti
- Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy
Eugenia Giaculli
- Dept of Dermatology, University G.D’Annunzio, Chieti, Italy
Salvatore Ruggeri
- Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy
Donatella Sordi
- Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy
Massimo Amatetti
- Dept of Dermatology, University G.D’Annunzio, Chieti, Italy
Luca Chinni
- Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy
Antonio Tulli
- Dept of Dermatology, University G.D’Annunzio, Chieti, Italy

published online 07 November 2006.

Summary

Darier's disease is a rare, genetically determined, chronic disorder of keratinization. Characterized clinically by a symmetrical eruption of hypercheratotic papules with predilection for the seborrhoeic areas of the body. Many treatments have been suggested: emollients, topical retinoids, dermoabrasion, topical steroids and intermittent courses of oral antibiotics. Systemic retinoids are usually the treatment of choice. We present a small case series of patients treated with PDT and topical retinoids with good results. This therapeutic modality could represent an alternative to systemic retinoid treatment.

Keywords: Photodinamic therapy, Darier disease, Local therapy