Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 1 , Pages 13-25 , March 2007

Research and development of photodynamic therapy photosensitizers in China

  • De-Yu Xu, PhD

      Affiliations

    • Corresponding Author InformationTel.: +86 21 65486187; fax: +86 21 35090750.

References 

  1. Dougherty TJ. Photoradiation therapy for treatment of malignant tumors. Cancer Res. 1978;38:2628–2635
  2. Beijing Institute of Pharmaceutical Industry: Aibulin (Hematoporphyrin). Supplement of Beijing Pharmaceutical Industry; 1983. p. 3–32, 40–63 [in Chinese].
  3. Liu YL, Zhu Z, Wu P, Yang SL. Studies on the porphyrin photosensitive drug YHpD. Acta Pharm Sin. 1985;20:619–622[in Chinese]
  4. Liu YL, Zhu LZ, Wu P, Bai YL. Chromatographic analysis of hematoporphyrin derivative and its active components. Acta Pharm Sin. 1984;19:706–709[in Chinese]
  5. Liu YL, Zhu LZ, Wu P. Separation and identification of hematoporphyrin derivative. Acta Pharm Sin. 1984;19:547–549[in Chinese]
  6. Liu YL, Yang SL, Bai YL, Shi SF, Wu ZG. Preparation and identification of hematoporphyrin dimethyl ester and its diacetyl derivatives. Acta Pharm Sin. 1985;20:545–547[in Chinese]
  7. Wang NQ, Yu G, Liang YY, Ye AL, Yuan QZ. A comparative study on the photodynamic effect, photosensitive action and toxicity of several domestic photosensitizers. Acta Pharm Sin. 1986;21:7–11[in Chinese]
  8. Xu DY, Yin XS, Liu J, Chen WH. Studies on hematoporphyrin photosensitizers. Acad J 2nd Mil Med Univ. 1983;4:161–165[in Chinese]
  9. Xu DY, Yin XS, Chen X, Chen WH, Liu J. Studies on the new photosensitizer PsD-007. Acad J 2nd Mil Med Univ. 1984;5:31–34[in Chinese]
  10. Xu DY, Yin XS, Chen X, Chen WH, Liu J. Studies on the chemistry of Photocarcinorin. J Med Coll PLA. 1987;2:7–13
  11. Zhang H, Xu DY. Studies on preparation and tumor photobiological activities of synthesized hematoporphyrin derivatives. Chin J Pharm. 1989;20:60–63[in Chinese]
  12. Xu DY, Yin XS, Chen WH, Chen X, Liu J. Studies on the new tumor photolocalizing and photochemotherapeutic agent Photocarcinorin (PsD-007). Chin J Pharm. 1989;20:440–446[in Chinese]
  13. Chen WH, Yin XS, Xu DY. Separation and identification of the major components of Photocarcinorin (PsD-007) and their tumor photobiological activities. J Med Coll PLA. 1991;6:309–318
  14. Xu DY, Yin XS, Chen WH, Zhang H. Studies on the new photolocalizing and photochemotherapeutic agent Photocarcinorin (PsD-007). SPIE Proc. 1991;1616:305–311
  15. Chen JY, Lu YM, Chen SM, Cai HX. The ability of some hematoporphyrin 3,8-akyloxy(thio)derivatives for photo-generating singlet oxygen. Photographic Sci Photochem. 1991;9:156–159
  16. Dong RC, Li FD, Xu DY, Gu HC, Chen JY, Zhu CS, et al. In vitro cancericidal effect of the new hematoporphyrin photosensitizer PsD-007 irradiated with light of different wavelength. Med J PLA. 1984;9:368–371[in Chinese]
  17. Peng Q, Dong RC. Photodynamic effects of Photocarcinorin (PsD-007) and Photofrin II on human cancer cells in vitro. Acad J 2nd Mil Med Univ. 1986;7:280–283[in Chinese]
  18. Chen WH, Ye HC, Liu J, Liang JQ, Xu DY. Efficacies of photolocalization and photochemotherapy of Photocarcinorin (PsD-007) for different transplanted animal tumors. Acad J 2nd Mil Med Univ. 1986;7:253–257[in Chinese]
  19. Shen NC, Yuan BJ, Tang HL, Li BC, Liu JP, Li YP, et al. Acute toxicity of the new hematoporphyrin photosensitizer PsD-007 in mice and dogs. Acta Pharm Sin. 1986;7:346–350[in Chinese]
  20. Yuan BJ, Tang HL, Li BC, Liu JP, Li YP, Shen NC. Subacute toxicity of the new tumor-photolocalizing and phototherapeutic agent PsD-007. Acad J 2nd Mil Med Univ. 1985;6:206–209[in Chinese]
  21. Zhang P, Dong RC, Lu FD. Pathalogical observation on the acute and subacute toxicity of new hematoporphyrin photosensitizer Photocarcinorin (PsD-007). Acad J 2nd Mil Med Univ. 1988;9:32–35[in Chinese]
  22. Yuan BJ, Li BC, Shen NC. Phototoxic reaction of the new photosensitizer PsD-007 in normal tissues. J 2nd Mil Med Univ. 1984;5:263–265[in Chinese]
  23. Xu DY, Shen NC. A new tumor-photolocalizing and photochemotherapeutic agent and radiosensitizer Photocarcinorin (PsD-007). J Med Coll PLA. 1992;7:90–102
  24. Xu YZ, Chen SL, Chen YD, Yin XS. Studies on clinical pharmacokinetics of Photocarcinorin post i.v. drip. Acad J 2nd Mil Med Univ. 1986;7:82–85[in Chinese]
  25. Xu DY. Principle, photosensitizers and introduction of clinical application. Tumor photodynamic therapy. Beijing: Chinese Medicinal Science and Technique Press; 1996;p. 188 [in Chinese]
  26. Xu DY, Chen WH, Zhang H, Shen NC. Hematoporphyrin 3-or 8-methyl ether: a promising candidate for tumor photodynamic therapy. J Med Coll PLA. 1993;8:406–409
  27. Gu Y, Li JH, Xu DY, Zhang ZQ, Wang K. A preliminary report of clinical application of hematoporphyrin monomethyl ether in photodynamic therapy for alimentary cancers. SPIE Proc. 1994;2371:385–387
  28. Gu Y, Liu FG, Wang K, Zhu JG, Liang J, Pan YM, et al. A clinic analysis of 1216 cases of port wine stan treated by photodynamic therapy. Chin J Laser Med Surg. 2001;10:86–89[in Chinese]
  29. Yu JX, Xu DY. Synthesis of new photosensitizer bezoporphyrin derivatives. Chin J Pharm. 1999;30:158–161[in Chinese]
  30. Yu JX, Xu DY, Chen WH, Zhan L. Efficacies of bezoporphyrin derivatives in photodynamic therapy for sarcoma S180 in mice. Chin J Laser Med Surg. 1999;8:85–87[in Chinese]
  31. Fang Y, Xu DY, Liu JF. Studies on synthesis of chlorin from reduction of porphyrins and their antitumor photobiological activities. Chin J Laser Med Surg. 2001;10:82–85[in Chinese]
  32. Wang SY, Xu DY. Synthesis and tumor-photobiological activities of meso-tetra(substitutedaryl)porphines. Acad J 2nd Mil Med Univ. 1989;10:110–114[in Chinese]
  33. Chen JY, Lu YM, Chen SM, Cai HX, Wang SY, Xu DY. An ESR study on singlet oxygen photoproduction of the meso-tetrakis-(substitutedphenyl)porphine derivatives. Chem J Chin Univ (Ser B). 1990;6:313–316
  34. Liu J, Hu LQ, Xu DY. Sensitizing effects of porphyrins on photooxidation of NADPH in deuterium oxide. Acad J 2nd Mil Med Univ. 1988;9:435–437[in Chinese]
  35. Zhong JX, Zhu LL, Li WJ, Yang YH. Photodynamic effects of Can-Sha photosensitizer on transplanted tumors in mice. SPIE Proc. 1991;1616:283–285
  36. Teng LS, Zheng S, Wu JM, Yu H, Cheng ZM. Photodynamic effect of chlorophyll derivative with pulsed copper vapor laser rectal carcinoma in vitro. SPIE Proc. 1991;1616:312–318
  37. Liu SS, Yang YH, Wang ZS. Clinical study of CPD4-PDT for the prevention of recurrence in infiltrative bladder cancer. Chin J Integrating Chin Med Mod Med. 1998;18:15–17[in Chinese]
  38. Liu SS, Yang YH, Wang ZS. Comparison study of CPD4-PDT and thio-TEPA instillation for the prevention of recurrence of bladder cancer. Zhejiang Med. 1998;20:69–71[in Chinese]
  39. Hu LQ, Xu DY. Separation and identification of pheophorbide a from acid degradation products of silkworm excrement chlorophyll mixture. Pharm Ind. 1988;19:157–160[in Chinese]
  40. Hu LQ, Xu DY. On the chemistry of pheophorbide a: a novel photosensitizer. Acad J 2nd Mil Med Univ. 1986;7:405–408[in Chinese]
  41. Hu LQ, Xu DY. HPLC separation and characterization of chlorinderivatives with intact ring V from acid degradation products of silkworm excrement crude chlorophyll mixture. Biomed Chromatogr. 1989;3:72–74
  42. Zhu Q, Xu DY, Zhang H. Separation and identification of phorbin derivatives. Chin J Pharm. 1992;23:212–214[in Chinese]
  43. Fang Y, Xu DY. Degradation of silkworm excrement crude chlorophyll and synthesis of chlorin e6 ether derivatives. Org Chem. 1995;15:493–498[in Chinese]
  44. Fang Y, Xu DY. Chlorn e6-6-methyl ester: a developing candidate for PDT. Chin Laser Med Surg. 1999;8:235–238[in Chinese]
  45. Zhang L, Xu DY. Synthesis of chlorin e6-6-amide derivatives. Org Chem. 1999;19:424–430[in Chinese]
  46. Zhang L, Xu DY. Sensitizing effects of chlorin e6-6-amides on photooxidation of NADPH in deuterium oxide. Chin J Laser Med Surg. 1999;8:232–234[in Chinese]
  47. Yao JZ, Chen WH, Xu DY. Studies on the degradation of silkworm excrement chlorophyll. Chin Tradit Herbal Drugs. 1999;30:568–571[in Chinese]
  48. Yao JZ, Chen WH, He X, et al. Synthesis, photosensitizing ability and tumor-photobiological activity of Chlorin f. Acta Pharm Sinica. 2000;35:63–65[in Chinese]
  49. Yao JZ, Chen WH, Shen WD, et al. Photodynamic efficacy of chlorin p6 amides for sarcoma S180 in mice. Acad J 2nd Mil Med Univ. 2001;22:861;[in Chinese]
  50. Chen FP, Xu DY. Synthesis of water soluble phthalocyanines. Org Chem. 1990;10:550–553[in Chinese]
  51. Huang JL, Chen NS, Huang JD, Liu ES, Xue JP, Yang SL. Metal phthalocyanines for photodynamic therapy: preparation, character and anticancer activities of amphipathy zinc phthalocyanine ZnPcS2P2. Sci China (B Ser). 2000;30:481–488[in Chinese]
  52. Huang JL, Chen NS, Liu ES, et al. Zinc phthalocyanine its preparation and application in tumor-photodynamic therapy. Chinese Patent ZL96117137.5, CN1053906C.
  53. Liu ES, Dai ZF, Huang JL, et al. Synthesis of metal phthalocyanines and photoinactivation for cancer cells. Acta Biochem Biophys. 1998;30:31–34[in Chinese]
  54. Liu ES, Huang JD, Huang JL. Synthesis and photodynamic anticancer activities of zinc methylenephthalimidylsulfophthalocyanine. Acta Inorg Chem. 1997;13:411–415[in Chinese]
  55. Wang WJ, Bai JY, Guan MZ, et al. Study on the pharmacokinetics of Photocyanine, a metal complex compound of phthalocyanine. Asia J Drug Metab Pharmacokinet. 2004;4:57–62
  56. Huang JL, Huang JD, Liu ES, Chen NS. Some relationships between structures and photodynamic activities of phthalocyanines. Acta Phys Chem Sin. 2001;17:662–671[in Chinese]
  57. Jiang LJ, He YY. Photophysics photochemistry and photobiology of hypocrellin photosensitizers. KEXUE TONGBAO. 2000;45:2019–2032
  58. Wan XY, Chen YT. Hypocrellin A: a new drug for photochemotherapy. KEXUE TONGBAO. 1981;126:1040–1042
  59. Cheng LS, Wang JZ. Photodamage in human erythrocyte membranes, induced by a new photosensitizer hypocrellin A. Acta Biol Exp Sin. 1985;18:89–97[in Chinese]
  60. Diwu Z, Lown W. Photosensitization with anticancer agents. 12. Perylene quinoid pigments, a novel type of singlet oxygen sensitizer. J Photochem Photobiol A: Chem. 1992;64:277–279
  61. Ester EP, Brown K, Diwu Z, et al. Hypocrellins as photosensitizer for photodynamic therapy, a screening evaluation and pharmacokinetic study. Cancer Chemother Pharmacol. 1996;37:343–350
  62. Liu HL, Gu Y, Liu FG, et al. Comparison of eleven photosensitizers’ phototoxicity under irradiation of copper vapor laser. Chin J Laser Med Surg. 2002;11:88–92[in Chinese]
  63. Huang Z. Photodynamic therapy in China: 25 years of unique history. Part One: History and domestic photosensitizers. Photodiagn Photodyn Ther. 2006;3:3–10
  64. Huang Z. Photodynamic therapy in China: 25 years of unique history. Part Two: Clinical experience. Photodiagn Photodyn Ther. 2006;3:71–84

PII: S1572-1000(06)00120-7

doi: 10.1016/j.pdpdt.2006.09.003

Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 1 , Pages 13-25 , March 2007