Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 3 , Pages 170-178 , September 2007

In vivo quantification of fluorescent molecular markers in real-time: A review to evaluate the performance of five existing methods

  • A. Bogaards, PhD

      Affiliations

    • University Health Network, Division of Biophysics and BioImaging, Toronto, M5G2MG Ontario, Canada
    • Erasmus University Medical Center, Center for Optical Diagnostics and Therapy, Department of Radiotherapy, Rotterdam POB 2040, 3000 CA Rotterdam, The Netherlands
    • Corresponding Author InformationCorresponding author at: University Health Network/Ontario Cancer Institute, 610 University Avenue, Rm 7-327, Toronto, Ontario M5G 2M9, Canada. Tel.: +1 416 946 4501x5747; fax: +1 416 946 6529.
    • ,
  • H.J.C.M. Sterenborg

      Affiliations

    • Erasmus University Medical Center, Center for Optical Diagnostics and Therapy, Department of Radiotherapy, Rotterdam POB 2040, 3000 CA Rotterdam, The Netherlands
    • ,
  • B.C. Wilson

      Affiliations

    • University Health Network, Division of Biophysics and BioImaging, Toronto, M5G2MG Ontario, Canada

References 

  1. Sullivan DC, Ferrari M. Nanotechnology and tumor imaging: seizing an opportunity. Mol Imaging. 2004;3:364–369
  2. Wagnieres G. Lung cancer imaging with fluorescence endoscopy. In:  Mycek M,  Pogue BW editor. Handbook of biomedical fluorescence. New York: Marcel Dekker; 2003;p. 361–396
  3. DaCosta RS, Wilson BC, Marcon NE. Light-induced fluorescence endoscopy of the gastrointestinal tract. Gastrointest Endosc. 2000;10:1–33
  4. de Veld DC, Witjes MJ, Sterenborg HJ, Roodenburg JL. The status of in vivo autofluorescence spectroscopy and imaging for oral oncology. Oral Oncol. 2005;41:117–131
  5. Aalders MC, Sterenborg HJCM, van der Vange N. Fluorescein angiography for the detection of metastases of ovarian tumor in the abdominal cavity, a feasibility pilot. Lasers Surg Med. 2004;35:349–353
  6. Stummer W, Gotz C, Hassan A, Heimann A, Kempski O. Kinetics of Photofrin II in perifocal brain edema. Neurosurgery. 1993;33:1075–1081discussion 1081-2
  7. Ntziachristos V, Ripoll J, Wang LV, Weissleder R. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol. 2005;23:313–320
  8. Cherry SR. In vivo molecular and genomic imaging: new challenges for imaging physics. Phys Med Biol. 2004;49:R13–R48
  9. Choy G, Choyke P, Libutti SK. Current advances in molecular imaging: noninvasive in vivo bioluminescent and fluorescent optical imaging in cancer research. Mol Imaging. 2003;2:303–312
  10. Sokolov K, Aaron J, Hsu B, et al. Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat. 2003;2:491–504
  11. Bogaards A, Aalders MC, Zeyl CC, et al. Localization and staging of cervical intraepithelial neoplasia using double ratio fluorescence imaging. J Biomed Opt. 2002;7:215–220
  12. Kumar AT, Skoch J, Bacskai BJ, Boas DA, Dunn AK. Fluorescence-lifetime-based tomography for turbid media. Opt Lett. 2005;30:3347–3349
  13. Roy R, Godavarty A, Sevick-Muraca EM. Fluorescence-enhanced optical tomography using referenced measurements of heterogeneous media. IEEE Trans Med Imaging. 2003;22:824–836
  14. Mansfield JR, Gossage KW, Hoyt CC, Levenson RM. Autofluorescence removal, multiplexing, and automated analysis methods for in-vivo fluorescence imaging. J Biomed Opt. 2005;10:41207
  15. Gao X, Cui Y, Levenson RM, Chung LW, Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol. 2004;22:969–976
  16. Graves EE, Yessayan D, Turner G, Weissleder R, Ntziachristos V. Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography. J Biomed Opt. 2005;10:44019
  17. Ntziachristos V, Schellenberger EA, Ripoll J, et al. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci USA. 2004;101:12294–12299
  18. Graves EE, Ripoll J, Weissleder R, Ntziachristos V. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Phys. 2003;30:901–911
  19. Flejou JF. Barrett's oesophagus: from metaplasia to dysplasia and cancer. Gut. 2005;54(Suppl. 1):i6–i12
  20. Profio A. Laser excited fluorescence of hematoporhyrinderivative for diagnosis of cancer. IEEE Quant Electron. 1984;QE20:1502–1507
  21. Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging. 2003;2:37–49
  22. Kircher MF, Weissleder R, Josephson L. A dual fluorochrome probe for imaging proteases. Bioconjug Chem. 2004;15:242–248
  23. Kircher MF, Josephson L, Weissleder R. Ratio imaging of enzyme activity using dual wavelength optical reporters. Mol Imaging. 2002;1:89–95
  24. Baumgartner R, Fisslinger H, Jocham D, et al. A fluorescence imaging device for endoscopic detection of early stage cancer—instrumental and experimental studies. Photochem Photobiol. 1987;46:759–763
  25. Xenogen® Corp. http://www.xenogen.com/wt/page/publications.
  26. Troy T, Jekic-McMullen D, Sambucetti L, Rice B. Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models. Mol Imaging. 2004;3:9–23
  27. Montan S, Svanberg K, Svanberg S. Multicolor imaging an contrast enhancement in cancer-tumor localization using laser-induced fluorescence in hematoporphyrin-derivative-bearing tissue. Opt Lett. 1985;10:56–58
  28. Sinaasappel M, Sterenborg HJCM. Quantification of the hematoporphyrin derivative by fluorescence measurement using dual-wavelength excitation and dual-wavelength detection. Appl Opt. 1993;32:541–548
  29. Saarnak AE, Rodrigues T, Schwartz J, et al. Influence of tumour depth, blood absorption and autofluorescence on measurement of exogenous fluorophores in tissue. Lasers Med Sci. 1998;13:22–31
  30. Farrell TJ, Patterson MS. Diffusion modeling of fluorescence in tissue. In:  Mycek M,  Pogue BW editor. Handbook of biomedical fluorescence. New York: Marcel Dekker; 2003;p. 29–60
  31. Svaasand LO, Norvang LT, Fiskerstrand EJ, Stopps EKS, Berrns MW, Nelson JS. Tissue parameters determining the visual appearance of normal skin and port-wine stain. Lasers Med Sci. 1995;10:55–65
  32. Amelink A, Sterenborg HJ, Bard MP, Burgers SA. In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy. Opt Lett. 2004;29:1087–1089
  33. Prahl S. http://omlc.ogi.edu/spectra/hemoglobin/index.html.
  34. van Veen RL, Sterenborg HJ, Marinelli AW, Menke-Pluymers M. Intraoperatively assessed optical properties of malignant and healthy breast tissue used to determine the optimum wavelength of contrast for optical mammography. J Biomed Opt. 2004;9:1129–1136
  35. Cheong W-F. Appendix to chapter 8: summary of optical properties. In:  Welch AJ,  van Gemert MJC editor. Optical–thermal response of laser-irradiated tissue. New York: Plenum Press; 1995;p. 275–303
  36. Wilson BC, Jacques SL. Optical reflectance and transmittance of tissues: principles and applications. IEEE J Quant Electron. 1990;26:2186–2198
  37. Lim YT, Kim S, Nakayama A, Stott NE, Bawendi MG, Frangioni JV. Selection of quantum dot wavelengths for biomedical assays and imaging. Mol Imaging. 2003;2:50–64
  38. Wilson BC, Weersink RA, Lilge L. Fluorescence in photodynamic therapy dosimetry. In:  Mycek M,  Pogue BW editor. Handbook of biomedical fluorescence. New York: Marcel Dekker; 2003;p. 529–561
  39. Bogaards A, Sterenborg HJCM, Trachtenberg J, Wilson BC, Lilge L. In vivo quantification of fluorescent molecular markers in real-time by ratio imaging for diagnostic screening and image-guided surgery. Lasers Surg Med, in press.

PII: S1572-1000(07)00031-2

doi: 10.1016/j.pdpdt.2007.02.003

Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 3 , Pages 170-178 , September 2007

Article Tools

* Image Usage & Resolution