Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 2 , Pages 117-123 , June 2007

Photodynamic effects of a novel series of silicon(IV) phthalocyanines against human colon adenocarcinoma cells

  • Pui-Chi Lo

      Affiliations

    • Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
    • ,
  • Stanley C.H. Leung

      Affiliations

    • Department of Biochemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
    • ,
  • Elaine Y.M. Chan

      Affiliations

    • Department of Biochemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
    • ,
  • Wing-Ping Fong

      Affiliations

    • Department of Biochemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
    • ,
  • Wing-Hung Ko

      Affiliations

    • Department of Physiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
    • ,
  • Dennis K.P. Ng, DPhil

      Affiliations

    • Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
    • Corresponding Author InformationCorresponding author. Tel.: +852 2609 6375; fax: +852 2603 5057.

References 

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  8. Huang J-D, Fong W-P, Chan EYM, et al. Photodynamic activities of a dicationic silicon(IV) phthalocyanine and its bovine serum albumin conjugates. Tetrahedron Lett. 2003;44:8029–8032
  9. Lee PPS, Ngai T, Huang J-D, et al. Synthesis, characterization, biodegradation, and in vitro photodynamic activities of silicon(IV) phthalocyanines conjugated axially with poly(ɛ-caprolactone). Macromolecules. 2003;36:7527–7533
  10. Huang J-D, Wang S, Lo P-C, et al. Halogenated silicon(IV) phthalocyanines with axial poly(ethylene glycol) chains. Synthesis, spectroscopic properties, complexation with bovine serum albumin and in vitro photodynamic activities. New J Chem. 2004;28:348–354
  11. Lo P-C, Huang J-D, Cheng DYY, et al. New amphiphilic silicon(IV) phthalocyanines as efficient photosensitizers for photodynamic therapy: Synthesis, photophysical properties, and in vitro photodynamic activities. Chem Eur J. 2004;10:4831–4838
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  17. Kalka K, Ahmad N, Criswell T, et al. Up-regulation of clusterin during phthalocyanine 4 photodynamic therapy-mediated apoptosis of tumor cells and ablation of mouse skin tumors. Cancer Res. 2000;60:5984–5987
  18. Whitacre CM, Feyes DK, Satoh T, et al. Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice. Clin Cancer Res. 2000;6:2021–2027
  19. Lam M, Oleinick NL, Nieminen A-L. Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells. J Biol Chem. 2001;276:47379–47386
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  21. Laville I, Figueiredo T, Loock B, et al. Synthesis, cellular internalization and photodynamic activity of glucoconjugated derivatives of tri and tetra(meta-hydroxyphenyl)chlorins. Bioorg Med Chem. 2003;11:1643–1652
  22. Banfi S, Caruso E, Caprioli S, et al. Photodynamic effects of porphyrin and chlorin photosensitizers in human colon adenocarcinoma cells. Bioorg Med Chem. 2004;12:4853–4860
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PII: S1572-1000(07)00034-8

doi: 10.1016/j.pdpdt.2007.03.001

Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 2 , Pages 117-123 , June 2007

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