Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 3 , Pages 184-189 , September 2007

Tetherless fiber-coupled optical sources for extended metronomic photodynamic therapy

  • Nick Davies, BSc (Hons), MSc

      Affiliations

    • Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto M5G 2M9, Canada
    • Corresponding Author InformationCorresponding author. Fax: +1 408 453 9293.
    • ,
  • Brian C. Wilson

      Affiliations

    • Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto M5G 2M9, Canada
    • Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto M5G 2M9, Canada

References 

  1. Wilson BC, Patterson MS. The physics of photodynamic therapy. Phys Med Biol. 1986;31:327–360
  2. Muller PJ, Wilson BC. Photodynamic therapy in primary brain tumours: clinical effects, postoperative ICP and light penetration of the brain. Photochem Photobiol. 1987;46:929–935
  3. Bisland SK, et al. Metronomic photodynamic therapy as a new paradigm for the treatment of malignant brain tumors. Photochem Photobiol. 2004;80:22–30
  4. Wilson BC, Bisland S, Bogaards A, et al. Metronomic photodynamic therapy (mPDT): concepts and technical feasibility in brain tumor. Proc SPIE. 2003;4952:23–31
  5. Boggards A, Varma A, Zhang K, et al. Fluorescence image-guided brain tumor resection with adjuvant metronomic photodynamic therapy: pre-clinical model and technology development. Photochem Photobiol Sci. 2005;4:438–442
  6. Lilge L, et al. The sensitivity of normal brain and intracranially implanted VX2 tumor to interstitial photodynamic therapy. Br J Cancer. 1996;73:332–343
  7. Weersink RA, et al. Techniques for delivery and monitoring of TOOKAD (WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalities. J Photochem Photobiol B Biol. 2005;79:211–222
  8. Karagiannis S, Chryssolouris G. Nd:YAG laser welding—an overview. Proc SPIE. 2003;5131
  9. Rathrnann FU, Russek UA. Laser welding of polymers. Using high power diode lasers. Proc SPIE. 2003;5121
  10. Hoult AP. Laser welding of polymer micro-fluidic devices using novel diode laser sources. Proc SPIE. 2003;5063
  11. Kruse CA, et al. A rat glioma model, CNS-1, with invasive characteristics similar to those of human gliomas: a comparison to 9L gliosarcoma. J Neurooncol. 1994;22:191–200
  12. Babilas P, Kohl E, Maisch T, et al. In vitro and in vivo comparison of two different light sources for topical photodynamic therapy. Br J Dermatol. 2006;154:712–718
  13. Juzeniene A, Juzenas P, Ma LW, Iani V, Moan J. Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy. Lasers Med Sci. 2004;19:139–149
  14. Taub AF. Photodynamic therapy in dermatology: history and horizons. J Drugs Dermatol. 2004;3:S8–S25
  15. Moriyama , et al. Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy. Photochem Photobiol. 2004;80:242–249
  16. Castano AP, Demidova TN, Hambli MR. Mechanisms in photodynamic therapy. Photodiagnos Photodyn Ther. 2004;1:279–293
  17. Berg , et al. A high performance connectorized LED package for fiber optics. IEEE Trans Components Hybrids Manufactur Technol. 1981;CHMT-4:337–344
  18. Uematsu , et al. Efficient power coupling between an MH LED and a taper-ended multimode fiber. IEEE J Quant Electron. 1979;QE-15:86–92
  19. Dutta , et al. High-brightness, AlGaInP-based visible light-emitting diode for efficient coupling with POF. IEEE Photon Technol Lett. 1995;7:1134–1136
  20. Park EH, Kim MJ, Kwon YS. Microlens for efficient coupling between LED and optical fiber. IEEE Photon Technol Lett. 1999;11:439–441
  21. Hirschberg H, Spetalen S, Carper S, Hole P, Tillung T, Madsen S. Minimally invasive photodynamic therapy (PDT) for ablation of experimental rat glioma. Minim Invasive Neurosurg. 2006;49:135–142
  22. Angell-Petersen E, Spetalen S, Madsen SJ, et al. Influence of light fluence rate on the effects of photodynamic therapy in an orthotopic rat glioma model. J Neurosurg. 2006;104:109–117
  23. Popovic EA, Kaye AH, Hill JS. Photodynamic therapy of brain tumors. J Clin Laser Med Surg. 1996;14:251–261
  24. Wood LM, Bellnier DA, Oseroff AR, Potter WR. Beam-splitting device for use with fiber-coupled laser light sources for photodynamic therapy. Photochem Photobiol. 2002;76:683–685

PII: S1572-1000(07)00035-X

doi: 10.1016/j.pdpdt.2007.03.005

Photodiagnosis and Photodynamic Therapy
Volume 4, Issue 3 , Pages 184-189 , September 2007

Article Tools

* Image Usage & Resolution