Photodiagnosis and Photodynamic Therapy
Volume 5, Issue 1 , Pages 2-9 , March 2008

Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light

  • Tanja Gabrecht

      Affiliations

    • Swiss Federal Institute of Technology (EPFL), Laboratory for Air and Soil Pollution, Station 6, Building CH, 1015 Lausanne, Switzerland
    • ,
  • Alexandre Radu

      Affiliations

    • The CHUV University Hospital, ENT Department, 1011 Lausanne, Switzerland
    • ,
  • Pierre Grosjean

      Affiliations

    • The CHUV University Hospital, ENT Department, 1011 Lausanne, Switzerland
    • ,
  • Bernd Weber

      Affiliations

    • Richard Wolf Endoscopes GmbH, 75438 Knittlingen, Germany
    • ,
  • Günther Reichle

      Affiliations

    • Clinic for Pneumology and Thoracic Surgery Hemer, Pneumology Department, 58675 Hemer, Germany
    • ,
  • Lutz Freitag

      Affiliations

    • Clinic for Pneumology and Thoracic Surgery Hemer, Pneumology Department, 58675 Hemer, Germany
    • ,
  • Philippe Monnier

      Affiliations

    • The CHUV University Hospital, ENT Department, 1011 Lausanne, Switzerland
    • ,
  • Hubert van den Bergh

      Affiliations

    • Swiss Federal Institute of Technology (EPFL), Laboratory for Air and Soil Pollution, Station 6, Building CH, 1015 Lausanne, Switzerland
    • ,
  • Georges Wagnières, PhD

      Affiliations

    • Swiss Federal Institute of Technology (EPFL), Laboratory for Air and Soil Pollution, Station 6, Building CH, 1015 Lausanne, Switzerland
    • Corresponding Author InformationCorresponding author. Tel.: +41 21 693 3120; fax: +41 21 693 3626.

References 

  1. Levi F, Lucchini F, La Vecchia C, Negri E, Levi F. Trends in mortality from major cancers in the European Union, including acceding countries, in 2004. Cancer. 2004;101:2843–2850
  2. Jemal A, Murray T, Ghafoor A, et al. Cancer Statistics, 2004. CA Cancer J Clin. 2004;54:8–29
  3. Liaw Y-P, Lien G-W, Huang Y-C. Patterns of lung cancer mortality in 23 countries: application of the age-period-cohort model. BMC Public Health. 2005;5
  4. Jemal A, Clegg LX, Ward E, et al. Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer. 2004;101:3–27
  5. Bepler G, Djulbegovic B, Clark RA, Tockman M. A systemic review and lessons learned from early lung cancer detection trial using low-dose computed tomography of the chest. Cancer Control. 2003;10:306–324
  6. Kato H. Photodynamic therapy for lung cancer—a review of 19 years’ experience. J Photochem Photobiol B Biol. 1998;42:96–99
  7. Hirsch FR, Franklin WA, Gazdar AF, Bunn PA. Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. Clin Cancer Res. 2001;7:5–22
  8. Goujon D, Zellweger M, Radu A, et al. In vivo autofluorescence imaging of early cancers in the human tracheobronchial tree with a spectrally optimized system. J Biomed Opt. 2003;8:17–25
  9. Wagnières G, McWilliams A, Lam S. Lung cancer imaging with fluorescence endoscopy. In:  Myceck M-A,  Pogue BW editor. Handbook of biomedical fluorescence. New York: Marcel Dekker, Inc.; 2003;p. 361–396
  10. Kennedy TC, Lam S, Hirsch FR. Review of recent advances in fluorescence bronchoscopy in early localization of central airway lung cancer. Oncologist. 2001;6:257–262
  11. Chhajed PN, Shibuya K, Hoshino H, et al. A comparison of video and autofluorescence bronchoscopy in patients at high risk of lung cancer. Eur Respir J. 2005;25:951–955
  12. Qu J, MacAulay C, Lam S, Palcic B. Optical properties of normal and carcinomatous bronchial tissue. Appl Opt. 1994;33:7397–7405
  13. Fisseler-Eckhoff A, Rothstein D, Müller KM. Neovascularization in hyperplastic, metaplastic and potentially preneoplastic lesions of the bronchial mucosa. Virchows Arch. 1996;429:95–100
  14. Fontanini G, Calcinai A, Boldrini L, et al. Modulation of neoangiogenesis in bronchial preneoplastic lesions. Oncol Rep. 1999;6:813–817
  15. Keith RL, Miller YE, Gemmill RM, et al. Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res. 2000;6:1616–1625
  16. Hürzeler D. Blue light endoscopy. Laryngoscope. 1975;85:1374–1378
  17. Zellweger M, Goujon D, Conde R, Forrer M, van den Bergh H, Wagnières G. Absolute autofluorescence spectra of human healthy, metaplastic, and early cancerous bronchial tissue in vivo. Appl Opt. 2001;40:3784–3791
  18. Zellweger M, Grosjean P, Goujon D, Monnier P, van den Bergh H, Wagnières G. In vivo autofluorescence spectroscopy of human bronchial tissue to optimize the detection and imaging of early cancers. J Biomed Opt. 2001;6:41–51
  19. Häußinger K, Stanzel F, Huber RM, Pichler J, Stepp H. Autofluorescence detection of bronchial tumors with the D-Light/AF. Diagn Ther Endosc. 1999;5:105–112
  20. Tercelj M, Zeng H, Petek M, Rott T, Palcic B. Acquisition of fluorescence and reflectance spectra during routine bronchoscopy examinations using the ClearVu Elite(TM) device: pilot study. Lung Cancer. 2005;50:35–42
  21. Bard MRL, Amelink A, Skurichina M, et al. Improving the specificity of fluorescence bronchoscopy for the analysis of neoplastic lesions of the bornchial tree by comvination with optical spectroscopy: preliminary communication. Lung Cancer. 2005;47:41–47
  22. Kara MA, Peters FP, Ten Kate FJW, Van Deventer SJ, Fockens P, Bergman JJGHM. Endoscopic video autofluorescence imaging may improve the detection of early neoplasia in patients with Barrett's esophagus. Gastrointest Endosc. 2005;61:679–685
  23. Ikeda N, Honda H, Hayashi A, et al. Early detection of bronchial lesions using newly developed videoendoscopy-based autofluorescence bronchoscopy. Lung Cancer. 2006;52:21–27
  24. Prahl S. Optical absorption of hemoglobin. [Internet] 1999 [cited 2006 24.03.2006]; Available from: http://omlc.ogi.edu/spectra/hemoglobin/.
  25. Kienle A, Lilge L, Vitkin AV, et al. Why do veins appear blue? A new look at an old question. Appl Opt. 1996;35:1151–1160

PII: S1572-1000(08)00004-5

doi: 10.1016/j.pdpdt.2008.01.005

Photodiagnosis and Photodynamic Therapy
Volume 5, Issue 1 , Pages 2-9 , March 2008

Article Tools

* Image Usage & Resolution