Photodiagnosis and Photodynamic Therapy
Volume 5, Issue 1 , Pages 19-28, March 2008

Bio-nanotechnology and photodynamic therapy—State of the art review

  • R.R. Allison

      Affiliations

    • Brody School of Medicine at ECU, Radiation Oncology, 600 Moye Blvd LJCC172, Greenville, NC 28758, United States
    • ,
  • H.C. Mota

      Affiliations

    • Brody School of Medicine at ECU, Radiation Oncology, 600 Moye Blvd LJCC172, Greenville, NC 28758, United States
    • ,
  • V.S. Bagnato

      Affiliations

    • Instituto de Fisica de São Carlos, Universidade de São Paulo, Av Trabalhadores Sancarlense, 400, São Carlos, SP 13566-590, Brazil
    • ,
  • C.H. Sibata, PhD

      Affiliations

    • Brody School of Medicine at ECU, Radiation Oncology, 600 Moye Blvd LJCC172, Greenville, NC 28758, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 252 744 2900; fax: +1 252 744 2812.

published online 28 February 2008.

Summary 

Photodynamic therapy (PDT) and bio-nanotechnology (NT) show striking similarities in clinical design and mechanistics. The PDT paradigm of photosensitizer application, light activation and singlet oxygen generation does in fact occur on the nanoscale level as does the resultant outcomes. NT has the ability to explain as well as modify each of the critical steps of PDT particularly photosensitizer design and delivery, light source miniaturization and optimization, location and intensity of the photodynamic reaction as well as offering a far greater insight into dosimetry and mechanisms of action. This review will explore the current and potential future interactions and modifications NT may have on PDT.

Keywords: Photodynamic therapy, Photodiagnosis, Nanotechnology, Review, Nanoparticles

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PII: S1572-1000(08)00009-4

doi:10.1016/j.pdpdt.2008.02.001

Photodiagnosis and Photodynamic Therapy
Volume 5, Issue 1 , Pages 19-28, March 2008

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