Photodiagnosis and Photodynamic Therapy
Volume 5, Issue 2 , Pages 120-126 , June 2008

Influence of drug-light-interval on photodynamic therapy of port wine stains—Simulation and validation of mathematic models

  • Naiyan Huang

      Affiliations

    • Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China
    • ,
  • Gang Cheng

      Affiliations

    • Department of Automatic Control, Beijing Institute of Technology, Beijing 100081, China
    • ,
  • Xiaosong Li

      Affiliations

    • Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China
    • ,
  • Ying Gu, PhD

      Affiliations

    • Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 10 66936304; fax: +86 10 68222584.
    • ,
  • Fanguang Liu

      Affiliations

    • Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China
    • ,
  • Qiuhai Zhong

      Affiliations

    • Department of Automatic Control, Beijing Institute of Technology, Beijing 100081, China
    • ,
  • Ying Wang

      Affiliations

    • Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China
    • ,
  • Jin Zen

      Affiliations

    • Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China
    • ,
  • Haixia Qiu

      Affiliations

    • Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China
    • ,
  • Hongxia Chen

      Affiliations

    • Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China

References 

  1. Li JH. Photodynamic therapy for port wine stains. Proc SPIE. 1998;3548:64–66
  2. Huang Z. Photodynamic therapy in China: 25 years of unique history—Part two: clinical experience. Photodiag Photodyn Ther. 2006;3:71–84
  3. Henderson BW, Dougherty TJ. How does photodynamic therapy work?. Photochem Photobiol. 1992;55:145–157
  4. Georgakoudi I, Nichols MG, Foster TH. The mechanism of Photofrin photobleaching and its consequences for photodynamic dosimetry. Photochem Photobiol. 1997;65:135–144
  5. Georgakoudi I, Foster TH. Singlet oxygen- versus nonsinglet oxygen-mediated mechanisms of sensitizer photobleaching and their effects on photodynamic dosimetry. Photochem Photobiol. 1998;67:612–625
  6. Finlay JC, Mitra S, Patterson MS, Foster TH. Photobleaching kinetics of Photofrin in vivo and in multicell tumour spheroids indicate two simultaneous bleaching mechanisms. Phys Med Biol. 2004;49:4837–4860
  7. Dysart JS, Singh G, Patterson MS. Calculation of singlet oxygen dose from photosensitizer fluorescence and photobleaching during mTHPC photodynamic therapy of MLL cells. Photochem Photobiol. 2005;81:196–205
  8. Dysart JS, Patterson MS. Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro. Phys Med Biol. 2005;50:2597–2616
  9. Sheng C, Hoopes PJ, Hasan T, Pogue BW. Photobleaching-based dosimetry predicts deposited dose in ALA-PpIX PDT of rodent esophagus. Photochem Photobiol. 2007;83:738–748
  10. Langmack K, Mehta R, Twyman P, Norris P. Topical photodynamic therapy at low fluence rates-theory and practice. J Photochem Photobiol B. 2001;60:37–43
  11. Zhou X, Pogue BW, Chen B, et al. Pretreatment photosensitizer dosimetry reduces variation in tumor response. Int J Radiat Oncol Biol Phys. 2006;64:1211–1220
  12. Verhoeven JW. Glossary of terms used in photochemistry. Pure Appl Chem. 1996;68:2223–2286
  13. Chen JY, Lu YM, Chen SM. The ability of some hematoporphyrin 3,8-alkyloxy(thio) derivative for photo-generating singlet oxygen. Photogr Sci Photochem. 1991;9:156–159[in Chinese]
  14. Verkruysse W, Pickering JW, Beek JF. Modeling the effect of wavelength on the pulsed dye laser treatment of port wine stains. Appl Opt. 1993;32:393–398
  15. Smithies DJ, Butler PH. Modelling the distribution of laser light in port-wine stains with the Monte Carlo method. Phys Med Biol. 1995;40:701–731
  16. Wang L, Jacques SL, Zheng L. MCML-Monte Carlo modeling of light transport in multi-layered tissues. Comput Methods Programs Biomed. 1995;47:131–146
  17. Chen B, Pogue BW, Hoopes PJ, Hasan T. Vascular and cellular targeting for photodynamic therapy. Crit Rev Eukaryot Gene Exp. 2006;16:279–305
  18. Xu YZ, Cheng SL, Cheng YD, Zhang XS, Zhang H. The study of clinical pharmacokinetics after PSD-007 intravenous injection. Acad J Second Mil Med Univ. 1986;7:82–85[in Chinese]
  19. Wang KK, Mitra S, Foster TH. A comprehensive mathematical model of microscopic dose deposition in photodynamic therapy. Med Phys. 2007;34:282–293
  20. Nichols MG, Foster TH. Oxygen diffusion and reaction kinetics in the photodynamic therapy of multicell tumour spheroids. Phys Med Biol. 1994;39:2161–2181
  21. Foster TH, Murant RS, Bryant RG, Knox RS, Gibson SL, Hilf R. Oxygen consumption and diffusion effects in photodynamic therapy. Radiat Res. 1991;126:296–303
  22. Zhou GY, Zhang ZY, Li J. Computed assessment of pathological images of 52 cases’ biopsies of port wine stain. Chin Soc Oral Maxillofac Surg. 1999;9:112–115[in Chinese]
  23. Gu Y, Jiang L, Zhao XM, et al. The impact of PDT on the skin perfusion of port wine stain. Chin J Laser Med Surg. 1995;4:151–154[in Chinese]
  24. Jiang L, Gu Y, Li X, et al. Changes of skin perfusion after photodynamic therapy for port wine stain. Chin Med J (Engl). 1998;111:136–138

PII: S1572-1000(08)00045-8

doi: 10.1016/j.pdpdt.2008.05.006

Photodiagnosis and Photodynamic Therapy
Volume 5, Issue 2 , Pages 120-126 , June 2008

Article Tools

* Image Usage & Resolution