Photodiagnosis and Photodynamic Therapy
Volume 5, Issue 3 , Pages 176-181 , September 2008

Changes in human skin after topical PDT with hexyl aminolevulinate

  • Asta Juzeniene

      Affiliations

    • Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway
    • Corresponding Author InformationCorresponding author. Tel.: +47 22935113; fax: +47 22934270.
    • ,
  • Kristian Pagh Nielsen

      Affiliations

    • Balter Medical AS, Thormøhlensgt. 55, N-5008 Bergen, Norway
    • ,
  • Lu Zhao

      Affiliations

    • Balter Medical AS, Thormøhlensgt. 55, N-5008 Bergen, Norway
    • ,
  • Gennady A. Ryzhikov

      Affiliations

    • Balter Medical AS, Thormøhlensgt. 55, N-5008 Bergen, Norway
    • ,
  • Marina S. Biryulina

      Affiliations

    • Balter Medical AS, Thormøhlensgt. 55, N-5008 Bergen, Norway
    • ,
  • Jakob J. Stamnes

      Affiliations

    • Balter Medical AS, Thormøhlensgt. 55, N-5008 Bergen, Norway
    • Department of Physics and Technology, University of Bergen, Allégt. 55, 5007 Bergen, Norway
    • ,
  • Knut Stamnes

      Affiliations

    • Department of Physics and Engineering Physics, Light and Life Laboratory, Stevens Institute of Technology, Castle Point on Hudson, NJ, USA
    • ,
  • Johan Moan

      Affiliations

    • Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway
    • Institute of Physics, University of Oslo, Blindern, 0316 Oslo, Norway

References 

  1. Braathen LR, Szeimies RM, Basset-Seguin N, et al. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005.. J Am Acad Dermatol. 2007;56(1):125–143
  2. Gold MH. Photodynamic therapy with lasers and intense pulsed light. Fac Plast Surg Clin North Am. 2007;15(2):145–160
  3. Nootheti PK, Goldman MP. Aminolevulinic acid-photodynamic therapy for photorejuvenation. Dermatol Clin. 2007;25(1):35–45
  4. Moan J, Bissonnette R. Skin preparation. Patent 2001; 10/275,557 US Patent 6,911,194 B2.
  5. Monfrecola G, Procaccini EM, D’Onofrio D, et al. Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light. J Photochem Photobiol B. 2002;68(2–3):147–155
  6. Sharfaei S, Juzenas P, Moan J, Bissonnette R. Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice. Arch Dermatol Res. 2002;294(5):237–242
  7. Henderson BW, Vaughan L, Bellnier DA, van Leengoed H, Johnson PG, Oseroff AR. Photosensitization of murine tumor, vasculature and skin by 5-aminolevulinic acid-induced porphyrin. Photochem Photobiol. 1995;62(4):780–789
  8. Schacht V, Szeimies RM, Abels C. Photodynamic therapy with 5-aminolevulinic acid induces distinct microcirculatory effects following systemic or topical application. Photochem Photobiol Sci. 2006;5(5):452–458
  9. Van der Veen N, Hebeda KM, de Bruijn HS, Star WM. Photodynamic effectiveness and vasoconstriction in hairless mouse skin after topical 5-aminolevulinic acid and single- or two-fold illumination. Photochem Photobiol. 1999;70(6):921–929
  10. Wang I, ndersson-Engels S, Nilsson GE, Wardell K, Svanberg K. Superficial blood flow following photodynamic therapy of malignant non-melanoma skin tumours measured by laser Doppler perfusion imaging. Br J Dermatol. 1997;136(2):184–189
  11. Foster TH, Murant RS, Bryant RG, Knox RS, Gibson SL, Hilf R. Oxygen consumption and diffusion effects in photodynamic therapy. Radiat Res. 1991;126(3):296–303
  12. Tromberg BJ, Orenstein A, Kimel S, et al. In vivo tumor oxygen tension measurements for the evaluation of the efficiency of photodynamic therapy. Photochem Photobiol. 1990;52(2):375–385
  13. Bissonnette R, Shapiro J, Zeng H, McLean DI, Lui H. Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata. Br J Dermatol. 2000;143(5):1032–1035
  14. Itoh Y, Ninomiya Y, Tajima S, Ishibashi A. Photodynamic therapy of acne vulgaris with topical delta-aminolaevulinic acid and incoherent light in Japanese patients. Br J Dermatol. 2001;144(3):575–579
  15. Hestenes K, Nielsen KP, Zhao L, Stamnes JJ, Stamnes K. Monte Carlo and discrete-ordinate simulations of spectral radiances in a coupled air-tissue system. Appl Opt. 2007;46(12):2333–2350
  16. Nielsen KP, Zhao L, Ryzhikov GA, et al. Retrieval of the physiological state of human skin from UV–VIS reflectance spectra—a feasibility study. J Photochem Photobiol B. 2008;93:23–31
  17. Zhao L, Nielsen KP, Juzeniene A, et al. Spectroscopic measurements of photoinduced processes in human skin after topical application of the hexyl ester of 5-aminolevulinic acid. J Environ Pathol Toxicol Oncol. 2006;25(1–2):307–320
  18. Nielsen KP, Lu Z, Juzenas P, Stamnes JJ, Stamnes K, Moan J. Reflectance spectra of pigmented and nonpigmented skin in the UV spectral region. Photochem Photobiol. 2004;80(3):450–455
  19. Nielsen KP, Juzeniene A, Juzenas P, Stamnes K, Stamnes JJ, Moan J. Choice of optimal wavelength for PDT: the significance of oxygen depletion. Photochem Photobiol. 2005;81(5):1190–1194
  20. Plaetzer K, Krammer B, Berlanda J, Berr F, Kiesslich T. Photophysics and photochemistry of photodynamic therapy: fundamental aspects. Lasers Med Sci. 2008;
  21. Tadokoro T, Yamaguchi Y, Batzer J, et al. Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation. J Invest Dermatol. 2005;124(6):1326–1332
  22. Yamaguchi Y, Hearing VJ. Melanocyte distribution and function in human skin. Effects of ultraviolet radiation. In:  Hearing VJ,  Leong SPL editor. Melanocytes to Melanoma: The Progression to Malignancy.. 1st ed.. Totowa: Humana Press, Inc.; 2005;p. 101–115
  23. Alexiades-Armenakas M. Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. J Drugs Dermatol. 2006;5(1):45–55
  24. Alster TS, Tanzi EL, Welsh EC. Photorejuvenation of facial skin with topical 20% 5-aminolevulinic acid and intense pulsed light treatment: a split-face comparison study. J Drugs Dermatol. 2005;4(1):35–38
  25. Goldman MP, Merial-Kieny C, Nocera T, Mery S. Comparative benefit of two thermal spring waters after photodynamic therapy procedure. J Cosmet Dermatol. 2007;6(1):31–35
  26. Wiegell SR, Stender IM, Na R, Wulf HC. Pain associated with photodynamic therapy using 5-aminolevulinic acid or 5-aminolevulinic acid methylester on tape-stripped normal skin. Arch Dermatol. 2003;139(9):1173–1177
  27. Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol. 2006;54(4):647–651
  28. Henderson BW, Fingar VH. Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor. Cancer Res. 1987;47(12):3110–3114
  29. Moan J, Sommer S. Oxygen dependence of the photosensitizing effect of hematoporphyrin derivative in NHIK 3025 cells. Cancer Res. 1985;45(4):1608–1610
  30. Pogue BW, O’Hara JA, Goodwin IA, et al. Tumor PO(2) changes during photodynamic therapy depend upon photosensitizer type and time after injection. Comp Biochem Physiol A Mol Integr Physiol. 2002;132(1):177–184

PII: S1572-1000(08)00073-2

doi: 10.1016/j.pdpdt.2008.07.001

Photodiagnosis and Photodynamic Therapy
Volume 5, Issue 3 , Pages 176-181 , September 2008

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