Photodiagnosis and Photodynamic Therapy
Volume 6, Issue 1 , Pages 12-18 , March 2009

Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white light

  • Xiaoye Schneider-Yin, PhD

      Affiliations

    • Central Laboratory, Triemli Hospital, Zurich, Switzerland
    • Corresponding Author InformationCorresponding author at: Central Laboratory, Triemli Hospital, Birmensdorferstr. 497, CH-8063 Zurich, Switzerland. Tel.: +41 44 466 23 35; fax: +41 44 466 27 09.
    • ,
  • Aida Kurmanaviciene

      Affiliations

    • Research Division, Department of Gynecology, University Hospital, Switzerland
    • ,
  • Marion Roth

      Affiliations

    • Central Laboratory, Triemli Hospital, Zurich, Switzerland
    • ,
  • Malgorzata Roos

      Affiliations

    • Biostatistics Unit, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland
    • ,
  • André Fedier

      Affiliations

    • Research Division, Department of Gynecology, University Hospital, Switzerland
    • ,
  • Elisabeth I. Minder

      Affiliations

    • Central Laboratory, Triemli Hospital, Zurich, Switzerland
    • ,
  • Heinrich Walt

      Affiliations

    • Research Division, Department of Gynecology, University Hospital, Switzerland

References 

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  2. Brown SB, Brown EA, Walker I. The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol. 2004;5:497–508
  3. Dorward AM, Fancher KS, Duffy TM, Beamer WG, Walt H. Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation. Br J Cancer. 2005;93:1137–1143
  4. Ladner DP, Steiner RA, Allemann J, Haller U, Walt H. Photodynamic diagnosis of breast tumours after oral application of aminolevulinic acid. Br J Cancer. 2001;84:33–37
  5. Frei KA, Bonel HM, Frick H, Walt H, Steiner RA. Photodynamic detection of diseased axillary sentinel lymph node after oral application of aminolevulinic acid in patients with breast cancer. Br J Cancer. 2004;90:805–809
  6. Crnolatac I, Huygens A, van Aerschot A, Busson R, Rozenski J, de Witte PA. Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives. Bioorg Med Chem. 2005;13:6347–6353
  7. Zhang W, Anker L, Law RE, et al. Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin Cancer Res. 1996;2:843–846
  8. Ladner DP, Klein SD, Steiner RA, Walt H. Synergistic toxicity of delta-aminolaevulinic acid-induced protoporphyrin IX used for photodiagnosis and hypericum extract, a herbal antidepressant. Br J Dermatol. 2001;144:916–918
  9. Puck TT, Marcus PI. A rapid method for viable cell titration and clone production with HeLa cells in tissue culture. Proc Natl Acad Sci USA. 1955;10:53–59
  10. Altman DG. Practical Statistics for Medical Research. Chapman & Hall; 1991;
  11. Steel GG, Peckham MJ. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Rad Oncol Biol Phys. 1979;5:85–91
  12. Kubin A, Wierrani F, Jindra RH, et al. Antagonistic effects of combination photosensitization by hypericin, meso-tetrahydroxyphenylchlorin (m-THPC) and photofrin II on Staphylococcus aureus. Drugs Exp Clin Res. 1999;25:13–21
  13. Bhuvaneswari R, Yuen GY, Chee SK, Olivo M. Hypericin-mediated photodynamic therapy in combination with Avastin (bevacizumab) improves tumor response by down regulating angiogenic proteins. Photochem Photobiol Sci. 2007;6:1275–1283
  14. Kleban J, Mikes J, Szillardiova B, et al. Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells. Photochem Photobiol. 2007;83:1174–1185
  15. Saw CL, Olivo M, Soo KC, Heng PW. Delivery of hypericin for photodynamic applications (mini-review). Cancer Lett. 2006;241:23–30

PII: S1572-1000(09)00027-1

doi: 10.1016/j.pdpdt.2009.02.001

Photodiagnosis and Photodynamic Therapy
Volume 6, Issue 1 , Pages 12-18 , March 2009

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