Photodiagnosis and Photodynamic Therapy
Volume 6, Issue 1 , Pages 28-40 , March 2009

Clinical and immunohistochemical assessment of vulval intraepithelial neoplasia following photodynamic therapy using a novel bioadhesive patch-type system loaded with 5-aminolevulinic acid

  • A. Zawislak

      Affiliations

    • Department of Gynaecology, Belfast City Hospital Trust, Lisburn Road, Belfast BT9 7AB, UK
    • ,
  • R.F. Donnelly

      Affiliations

    • School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    • ,
  • W.G. McCluggage

      Affiliations

    • Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BA, UK
    • ,
  • J.H. Price

      Affiliations

    • Department of Gynaecology, Belfast City Hospital Trust, Lisburn Road, Belfast BT9 7AB, UK
    • ,
  • H.R. McClelland

      Affiliations

    • Department of Gynaecology, Belfast City Hospital Trust, Lisburn Road, Belfast BT9 7AB, UK
    • ,
  • A.D. Woolfson

      Affiliations

    • School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    • ,
  • S. Dobbs

      Affiliations

    • Department of Gynaecology, Belfast City Hospital Trust, Lisburn Road, Belfast BT9 7AB, UK
    • ,
  • P. Maxwell

      Affiliations

    • Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BA, UK
    • ,
  • P.A. McCarron, PhD

      Affiliations

    • Department of Pharmacy and Pharmaceutical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
    • Corresponding Author InformationCorresponding author at: Department of Pharmacy and Pharmaceutical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK. Tel.: +44 028 703 23285; fax: +44 028 7032 4965.

References 

  1. Jones RW, Baranyai J, Stables S. Trends in squamous cell carcinoma of the vulva: the influence of vulvar intraepithelial neoplasia. Obstet Gynecol. 1997;90:448–452
  2. Joura EA, Losch A, Haider-Angeler MG, Breitenecker G, Leodolter S. Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women. J Reprod Med. 2000;45:613–615
  3. Jones RW. Regarding management of VIN 3. Int J Gynecol Cancer. 1999;9:264
  4. Thuesen B, Andreasson B, Bock JE. Sexual function and somatopsychic reactions after local excision of vulvar intra-epithelial neoplasia. Acta Obstet Gynecol Scand. 1992;71:126–128
  5. Reid R. Superficial laser vulvectomy. I. The efficacy of extended superficial ablation for refractory and very extensive condylomas. Am J Obstet Gynecol. 1985;15(151):1047–1052
  6. Kuppers V, Stiller M, Somville T, Bender HG. Risk factors for recurrent VIN. The role of multifocality of disease. J Reprod Med. 1997;42:140–144
  7. Hillemanns P, Untch M, Dannecker C, et al. Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid. Int J Cancer. 2000;85:649–653
  8. Fehr MK, Hornung R, Schwarz VA, Simeon R, Haller U, Wyss P. Photodynamic therapy of vulvar intraepithelial neoplasia III using topically applied 5-aminolevulinic acid. Gynecol Oncol. 2001;80:62–66
  9. Abdel-Hady ES, Martin-Hirsch P, Duggan-Keen M, et al. Immunological and viral factors associated with the response of vulval intraepithelial neoplasia to photodynamic therapy. Cancer Res. 2001;61:192–196
  10. Peng Q, Warloe T, Berg K, et al. 5-aminolevulinc acid based photodynamic therapy. Clinical research and future challenge. Cancer. 1997;79:2282–2308
  11. Kennedy JC, Pottier RH, Pross DC. Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B. 1990;6:143–148
  12. Kennedy JC, Marcus SL, Pottier RH. Photodynamic therapy and photodiagnosis using endogenous photosensitization induced by 5-aminolevulinic acid; mechanism and clinical research. J Clin Laser Med Surg. 1996;14:289–304
  13. Corti L, Mazzarotto R, Belfontali S, et al. Photodynamic therapy in gynaecological neoplastic diseases. J Photochem Photobiol B. 1996;36:193–197
  14. Fehr MK, Hornung R, Degen A, et al. Photodynamic therapy of vulvar and vaginal condyloma and intraepithelial neoplasia using topically applied 5-aminolevulinic acid. Lasers Surg Med. 2002;30:273–279
  15. Gannon MJ, Brown SB. Photodynamic therapy and its applications in gynaecology. B J Obstet Gynaecol. 1999;106:1246–1254
  16. McCarron PA, Ma LW, Juzenas P, et al. Facilitated delivery of ALA to inaccessible regions via bioadhesive patch systems. J Environ Pathol Toxicol Oncol. 2006;25:389–402
  17. McCarron PA, Donnelly RF, Zawislak A, Woolfson AD. Design and evaluation of a water-soluble bioadhesive patch formulation for cutaneous delivery of aminolevulinic acid to superficial neoplastic lesions. Eur J Pharm Sci. 2006;27:268–279
  18. McCarron PA, Donnelly RF, Zawislak A, Woolfson AD, Price JH, McClelland R. Evaluation of a water-soluble bioadhesive patch for photodynamic therapy of vulval lesions. Int J Pharm. 2005 April;293:11–23
  19. Kessel D, Luo Y. Mitichondrial photodamage ad PDT induced apoptosis. J Photochem Photobiol B. 1998;42:89–95
  20. He XY, Sikes RA, Thomsen S, Chung LW, Jaques SL. Photodynamic therapy with photofrin II induces programmed cell death in carcinoma cell lines. Photochem Photobiol. 1994;5(59):468–473
  21. Gantrez® AN-139 Production Bulletin, ISP Europe Ltd.; 1996.
  22. McCarron PA, Woolfson AD, Donnelly RF, Andrews GP, Zawislak A, Price JH. Influence of plasticiser type and storage conditions on the properties of poly(methyl vinyl ether-co-maleic anhydride) bioadhesive films. J Appl Polym Sci. 2004;91:1576–1589
  23. Zawislak AA, Price JH, Dobbs SP, McClelland HR, McCluggage WG. The management of vulval intraepithelial neoplasia in Northern Ireland. Int J Gynecol Cancer. 2006;16:780–785
  24. Morton CA, Brown SB, Collins S, et al. guidelines for topical photodynamic therapy: a report of a workshop of the British photodermatology group. Br J Dermatol. 2002;146:552–567
  25. Fehr MK, Chapman CF, Krasieva T, McCullough JL, Berns MW. Selective photosensitizer distribution in vulvar condyloma acuminatum after topical application of 5-aminolevulinic acid. Am J Obstet Gynecol. 1996;174:951–957
  26. Hillemanns P, Weingandt H, Stepp H, et al. Assessment of 5-aminolevulinic acid-induced porphyrin fluorescence in patients with peritoneal endometriosis. Am J Obstet Gynecol. 2000;183:52–57
  27. Jones RW, Rowan DM, Stewart AW. Vulvar intraepithelial neoplasia: aspects of the natural history and outcome in 405 women. Obstet Gynecol. 2005;106:1319–1326
  28. Rosenthal AN, Hopster D, Ryan A, Jacobs IJ. Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma. Br J Cancer. 2003;27(88):251–256
  29. Nogueira MC, Guedes Neto Ede P, Rosa MW, Zettler E, Zettler CG. Immunohistochemical expression of p16 and p53 in vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva. Pathol Oncol Res. 2006;12:153–157
  30. Val IC, Almeida Gf , Valiante PM, et al. Vulvar intraepithelial neoplasia p53 expression in recurrent/progressive cases. J Reprod Med. 2004;49:868–874
  31. Kohlberger PD, Kirnbauer R, Bncher D, et al. Absence of p53 overexpression in precancerous lesions of the vulva. Cancer. 1998;82:323–327
  32. Roninson IB. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett. 2002;8(179):1–14
  33. Weinberg WC, Denning MF. P21Waf1 control of epithelial cell cycle and cell fate. Crit Rev Oral Biol Med. 2002;13:453–464
  34. Knopp S, Bjorge T, Nesland JM, Trope C, Scheistroen M, Holm R. p16INK4a and p21Waf1/Cip1 expression correlates with clinical outcome in vulvar carcinomas. Gynecol Oncol. 2004;95:37–45
  35. Yamaguchi S, Tsuda H, Takemori M, et al. Photodynamic therapy for cervical intraepithelial neoplasia. Oncology. 2005;69:110–116
  36. Ichimura H, Yamaguchi S, Kojima A, et al. Eradication and reinfection of human papillomavirus after photodynamic therapy for cervical intraepithelial neoplasia. Int J Clin Oncol. 2003;8:322–325
  37. van Hoeven KH, Kovatich AJ. Immunohistochemical staining for proliferating cell nuclear antigen, Bcl-2 and Ki-67 in vulvar tissues. Int J Gynecol Pathol. 1996;15:10–16
  38. Scopa CD, Tsamandas AC, Zolota V, Kalofonos HP, Batistatou A, Vagianos C. Potential role of bcl-2 and ki-67 expression and apoptosis in colorectal carcinoma: a clinicopathologic study. Dig Dis Sci. 2003;48:1990–1997
  39. Baisch H. Elevated Ki-67 expression is correlated with TNFalpha- and IFNgamma-induced apoptosis in tumour cells. Cell Prolif. 2002;35:333–342
  40. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000;182:311–322
  41. van Beurden M, de Craen AJ, de Vet HC, et al. The contribution of MIB 1 in the accurate grading of vulvar intraepithelial neoplasia. J Clin Pathol. 1999;52:820–824
  42. Nakaseko H, Kobayashi M, Akita Y, Tamada Y, Matsumoto Y. Histological changes and involvement of apoptosis after photodynamic therapy for actinic keratoses. Br J Dermatol. 2003;148:122–127
  43. Shahzidi S, Stokke T, Soltani H, Nesland JM, Peng Q. Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line320DM. J Environ Pathol Toxicol Oncol. 2006;25:159–171
  44. Gad F, Viau G, Boushira M, Bertrand R, Bissonnette R. Photodynamic therapy with 5-aminolevulinic acid induces apoptosis and caspase activation in malignant T cells. J Cutan Med Surg. 2001;5:8–13

PII: S1572-1000(09)00031-3

doi: 10.1016/j.pdpdt.2009.03.004

Photodiagnosis and Photodynamic Therapy
Volume 6, Issue 1 , Pages 28-40 , March 2009

Article Tools

* Image Usage & Resolution