Photodiagnosis and Photodynamic Therapy
Volume 6, Issue 2 , Pages 122-127 , June 2009

Induction of early apoptosis in human nasopharyngeal carcinoma cells by mTHPC-mediated photocytotoxicity

  • Christine M.N. Yow, PhD

      Affiliations

    • Medical Laboratory Science, Department of Health Technology Informatics, Hong Kong Polytechnic University, Hong Kong SAR, China
    • Corresponding Author InformationCorresponding author. Tel.: +852 3400 8575; fax: +852 2362 4365.
  • ,
  • N.K. Mak

      Affiliations

    • Department of Biology, Hong Kong Baptist University, Hong Kong SAR, China
  • ,
  • Albert W.N. Leung

      Affiliations

    • Department of Biology, Hong Kong Baptist University, Hong Kong SAR, China
  • ,
  • Zheng Huang

      Affiliations

    • Department of Radiation Oncology, University of Colorado Denver, CO, USA

References 

  1. Huang Z, Li L, Wang H, et al. Photodynamic therapy–an update on clinical applications. J Innov Opt Health Sci. 2009;2:73–92
  2. Sun ZQ, Luo GY. Photodynamic therapy for recurrent nasopharyngeal carcinoma after radiotherapy (An analysis of 191 cases). Chin J Laser Med Surg. 1996;5:134–136[in Chinese]
  3. Tong MC, van Hasselt CA, Woo JK . Preliminary results of photodynamic therapy for recurrent nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol. 1996;253:189–192
  4. Huang Z. Photodynamic therapy in China: 25 years of unique history–Part two: Clinical experience. Photodiag Photodyn Ther. 2006;3:71–84
  5. Li L, Luo R, Liao W, et al. Clinical study of Photofrin photodynamic therapy for the treatment of relapse nasopharyngeal carcinoma. Photodiag Photodyn Ther. 2006;3:266–271
  6. Lai J, Tao Z, Xiao J, et al. Effect of photodynamic therapy (PDT) on the expression of pro-apoptotic protein Bak in nasopharyngeal carcinoma (NPC). Lasers Surg Med. 2001;29:27–32
  7. Ali SM, Chee SK, Yuen GY, Olivo M. Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells. Int J Mol Med. 2002;9:601–616
  8. Koon H, Leung AW, Yue KK, Mak NK. Photodynamic effect of curcumin on NPC/CNE2 cells. J Environ Pathol Toxicol Oncol. 2006;25:205–215
  9. Wu RW, Chu ES, Yow CM, Chen JY. Photodynamic effects on nasopharyngeal carcinoma (NPC) cells with 5-aminolevulinic acid or its hexyl ester. Cancer Lett. 2006;242:112–119
  10. Li KM, Sun X, Koon HK, et al. Apoptosis and expression of cytokines triggered by pyropheophorbide-a methyl ester-mediated photodynamic therapy in nasopharyngeal carcinoma cells. Photodiag Photodyn Ther. 2006;3:247–258
  11. Xu CS, Leung AW. Photodynamic effects of pyropheophorbide-a methyl ester in nasopharyngeal carcinoma cells. Med Sci Monit. 2006;12:BR257–BR262
  12. D’Cruz AK, Robinson MH, Biel MA . mTHPC-mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study of 128 patients. Head Neck. 2004;26:232–240
  13. Yow CM, Chen JY, Mak NK, Cheung NH, Leung AW. Cellular uptake, subcellular localization and photodamaging effect of temoporfin (mTHPC) in nasopharyngeal carcinoma cells: comparison with hematoporphyrin derivative. Cancer Lett. 2000;157:123–131
  14. Yow CM, Mak NK, Szeto S, et al. Photocytotoxic and DNA damaging effect of temoporfin (mTHPC) and merocyanine 540 (MC540) on nasopharyngeal carcinoma cell. Toxicol Lett. 2000;115:53–61
  15. Marchal S, Bezdetnaya L, Guillemin F. Modality of cell death induced by Foscan-based photodynamic treatment in human colon adenocarcinoma cell line HT29. Biochemistry (Mosc). 2004;69:45–49
  16. Marchal S, Fadloun A, Maugain E, et al. Necrotic and apoptotic features of cell death in response to Foscan photosensitization of HT29 monolayer and multicell spheroids. Biochem Pharmacol. 2005;69:1167–1176
  17. Gomer CJ. Preclinical examination of first and second generation photosensitizers used in photodynamic therapy. Photochem Photobiol. 1991;54:1093–1107
  18. Huang DP, Ho JH, Poon YF, et al. Establishment of a cell line (NPC/HK1) from a differentiated squamous carcinoma of the nasopharynx. Int J Cancer. 1980;26:127–132
  19. Kessel D, Sun HH. Enhanced responsiveness to photodynamic therapy-induced apoptosis after mitochondrial DNA depletion. Photochem Photobiol. 1999;70:937–940
  20. Xue LY, Chiu SM, Oleinick NL. Photochemical destruction of the Bcl-2 oncoprotein during photodynamic therapy with the phthalocyanine photosensitizer Pc 4. Oncogene. 2001;20:3420–3427
  21. Waterhouse NJ, Trapani JA. A new quantitative assay for cytochrome c release in apoptotic cells. Cell Death Differ. 2003;10:853–855
  22. Chen JY, Mak NK, Yow CM, Fung MC, et al. The binding characteristics and intracellular localization of temoporfin (mTHPC) in myeloid leukemia cells: phototoxicity and mitochondrial damage. Photochem Photobiol. 2000;72:541–547
  23. Green DR, Amarante-Mendes GP. The point of no return: mitochondria, caspases, and the commitment to cell death. Results Probl Cell Differ. 1998;24:45–61
  24. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322–1326
  25. Granville DJ, Carthy CM, Jiang H, et al. Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy. FEBS Lett. 1998;437:5–10
  26. Vantieghem A, Xu Y, Declercq W, et al. Different pathways mediate cytochrome c release after photodynamic therapy with hypericin. Photochem Photobiol. 2001;74:133–142
  27. Castano AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part two - cellular signaling, cell metabolism and modes of cell death. Photodiag Photodyn Ther. 2005;2:1–23
  28. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312–1316
  29. Teiten MH, Bezdetnaya L, Morlière P, Santus R, Guillemin F. Endoplasmic reticulum and Golgi apparatus are the preferential sites of Foscan localisation in cultured tumour cells. Br J Cancer. 2003;88:146–152
  30. Teiten MH, Marchal S, D’Hallewin MA, Guillemin F, Bezdetnaya L. Primary photodamage sites and mitochondrial events after Foscan photosensitization of MCF-7 human breast cancer cells. Photochem Photobiol. 2003;78:9–14
  31. Triesscheijn M, Ruevekamp M, Aalders M, Baas P, Stewart FA. Outcome of mTHPC mediated photodynamic therapy is primarily determined by the vascular response. Photochem Photobiol. 2005;81:1161–1167
  32. Kessel D, Castelli M. Evidence that bcl-2 is the target of three photosensitizers that induce a rapid apoptotic response. Photochem Photobiol. 2001;74:318–322
  33. Marchal S, François A, Dumas D, Guillemin F, Bezdetnaya L. Relationship between subcellular localisation of Foscan and caspase activation in photosensitised MCF-7 cells. Br J Cancer. 2007;96:944–951

PII: S1572-1000(09)00058-1

doi: 10.1016/j.pdpdt.2009.06.003

Photodiagnosis and Photodynamic Therapy
Volume 6, Issue 2 , Pages 122-127 , June 2009