Photodiagnosis and Photodynamic Therapy
Volume 7, Issue 2 , Pages 123-125, June 2010

Topical treatment of disseminated superficial actinic porokeratosis with hypericin—photodynamic therapy: A case report☆

  • Annelies Boiy

      Affiliations

    • Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, K.U.Leuven, Herestraat 49, 3000 Leuven, Belgium
    • ,
  • Peter A.M. de Witte, PhD

      Affiliations

    • Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, K.U.Leuven, Herestraat 49, 3000 Leuven, Belgium
    • ,
  • Rik Roelandts, MD, PhD

      Affiliations

    • Photodermatology Unit, University Hospital, K.U.Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
    • Corresponding Author InformationCorresponding author. Tel.: +32 16 337001; fax: +32 16 337010.

published online 01 April 2010.

Summary 

Hypericin is a photo-active dye originating from the St. John's wort. Two patients with disseminated superficial actinic porokeratosis (DSAP) were treated with photodynamic therapy (PDT) using topical hypericin. Although a partial response was obtained in one patient topical hypericin-PDT does not emerge as a promising treatment for DSAP.

Abbreviations: DSAP, disseminated superficial actinic keratosis, PDT, photodynamic therapy

Keywords: Hypericin, Actinic porokeratosis, PDT

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☆ Research funded by a PhD grant of the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen).

PII: S1572-1000(10)00030-X

doi:10.1016/j.pdpdt.2010.02.003

Photodiagnosis and Photodynamic Therapy
Volume 7, Issue 2 , Pages 123-125, June 2010

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