Topical treatment of disseminated superficial actinic porokeratosis with hypericin—photodynamic therapy: A case report☆

published online 01 April 2010.

Summary

Hypericin is a photo-active dye originating from the St. John's wort. Two patients with disseminated superficial actinic porokeratosis (DSAP) were treated with photodynamic therapy (PDT) using topical hypericin. Although a partial response was obtained in one patient topical hypericin-PDT does not emerge as a promising treatment for DSAP.

Abbreviations: DSAP, disseminated superficial actinic keratosis, PDT, photodynamic therapy

Keywords: Hypericin, Actinic porokeratosis, PDT

a Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, K.U.Leuven, Herestraat 49, 3000 Leuven, Belgium

b Photodermatology Unit, University Hospital, K.U.Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium

Corresponding author. Tel.: +32 16 337001; fax: +32 16 337010.

☆ Research funded by a PhD grant of the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen).

PII: S1572-1000(10)00030-X

doi:10.1016/j.pdpdt.2010.02.003

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