Photodiagnosis and Photodynamic Therapy
Volume 7, Issue 2 , Pages 123-125 , June 2010

Topical treatment of disseminated superficial actinic porokeratosis with hypericin—photodynamic therapy: A case report

  • Annelies Boiy

      Affiliations

    • Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, K.U.Leuven, Herestraat 49, 3000 Leuven, Belgium
    • ,
  • Peter A.M. de Witte, PhD

      Affiliations

    • Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, K.U.Leuven, Herestraat 49, 3000 Leuven, Belgium
    • ,
  • Rik Roelandts, MD, PhD

      Affiliations

    • Photodermatology Unit, University Hospital, K.U.Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
    • Corresponding Author InformationCorresponding author. Tel.: +32 16 337001; fax: +32 16 337010.

References 

  1. Shumack SP, Commens CA. Disseminated superficial actinic porokeratosis: a clinical study. J Am Acad Dermatol. 1989;20:1015–1022
  2. Xia JH, Yang YF, Deng H, et al. Identification of a locus for disseminated superficial actinic porokeratosis at chromosome 12q23.2-24.1. J Invest Dermatol. 2000;114:1071–1074
  3. Nayeemuddin FA, Wong M, Yell J, Rhodes LE. Topical photodynamic therapy in disseminated superficial actinic porokeratosis. Clin Exp Dermatol. 2002;27:703–706
  4. Cavicchini S, Tourlaki A. Successful treatment of disseminated superficial actinic porokeratosis with methyl aminolevulinate-photodynamic therapy. J Dermatol Treat. 2006;17:190–191
  5. Fernandez-Guarino M, Harto A, Perez-Garcia B, Martin-Gonzalez M, Urrutia S, Jaen P. Photodynamic therapy in disseminated superficial actinic porokeratosis. JEADV. 2009;23:176–177
  6. Morton CA, Brown SB, Collins S, et al. Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group. Br J Dermatol. 2002;146:552–567
  7. Boiy A, Roelandts R, de Witte P. Influence of application and formulation factors on the penetration of hypericin in normal mouse skin and UV induced skin tumours. J Photochem Photobiol B. 2007;89:156–162
  8. Boiy A, Roelandts R, Roskams T, de Witte PAM. Effect of vehicles and esterification on the penetration and distribution of hypericin in the skin of hairless mice. Photodiagn Photodyn Ther. 2007;4:130–139
  9. Boiy A, Roelandts R, van den Oord J, de Witte P. Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin. Br J Dermatol. 2008;158:360–369

☆ Research funded by a PhD grant of the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen).

PII: S1572-1000(10)00030-X

doi: 10.1016/j.pdpdt.2010.02.003

Photodiagnosis and Photodynamic Therapy
Volume 7, Issue 2 , Pages 123-125 , June 2010

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