Letter to the EditorTreatment of recurrent pharyngotonsillitis by photodynamic therapy
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Acknowledgements
This study was supported by São Paulo Research Foundation (FAPESP; CEPOF Grant n° 13/07276-1) and National Council for Scientific and Technological Development (CNPq Grant n° 506243/2013-3). Special thanks to Cristina Kurachi for important discussions.
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2021, Journal of Photochemistry and PhotobiologyCitation Excerpt :Photodynamic inactivation, due to its multi-targeted reactive oxygen species (ROS)-mediated action mechanism, has shown so far a low probability for resistance development in bacteria. [59] Thus, PDI may be a suitable candidate for widespread use in the early stage nasal-tract infections and also in the treatment of severely ill patients that are unresponsive to other medication, as it is possible to irradiate the respiratory tract [60,61] through an endoscopic optic fiber. This has already been demonstrated in the treatment of lung cancer. [62,63]
Antimicrobial photodynamic therapy in dentistry using an oil-in-water microemulsion with curcumin as a mouthwash
2020, Photodiagnosis and Photodynamic TherapyCitation Excerpt :mL−1, followed by MRSA (gram-positive bacteria) and C. albicans (fungi). These results contrasted with some previously reported studies on PDT with curcumin [26–28], in which the greatest reduction observed was of gram-positive bacteria followed by gram-negative ones. Our results were related to the composition of the developed mouthwash formulation, including the nonionic surfactant polysorbate 80.
Evolution of surviving Streptoccocus pyogenes from pharyngotonsillitis patients submit to multiple cycles of antimicrobial photodynamic therapy
2020, Journal of Photochemistry and Photobiology B: BiologyCitation Excerpt :Photosensitizer (PS) and light at the appropriate wavelength in the presence of molecular oxygen form reactive oxygen species (ROS), leading to the death of tumors, bacteria, fungus and viruses [3–5]. Recently, demonstrations of the potential for pharyngotonsillitis treatment have shown significant results and an enormous potential for use [6]. Despite its benefits, aPDT has limitations that can influence treatment protocols, especially in multiple cycles, since the surviving cells were exposed to sub-conditions (PS and light) [7].
COVID-19: Beyond the virus. The use of photodynamic therapy for the treatment of infections in the respiratory tract
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